Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Dofetilide
Drug ID BADD_D00701
Description Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter.
Indications and Usage For the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter [AF/AFl]) in patients with atrial fibrillation/atrial flutter of greater than one week duration who have been converted to normal sinus rhythm
Marketing Status approved; investigational
ATC Code C01BD04
DrugBank ID DB00204
KEGG ID D00647
MeSH ID C063533
PubChem ID 71329
TTD Drug ID D0NW3X
NDC Product Code 0069-5810; 51862-005; 69452-133; 63190-0670; 42291-413; 42794-044; 51862-125; 14096-192; 29902-0014; 42291-411; 69452-131; 72205-041; 72664-229; 49812-0261; 16714-842; 42794-046; 47335-061; 47335-063; 59651-120; 72603-130; 72603-132; 16714-840; 16729-490; 16729-492; 59651-118; 69539-131; 0069-5820; 69452-132; 72664-231; 0904-6681; 50137-4245; 42291-412; 42794-045; 51862-025; 59651-119; 69539-130; 72664-230; 0904-6682; 0904-6683; 59651-038; 63190-0680; 0069-5800; 72205-040; 42413-0170; 63278-1079; 76055-0013; 16714-841; 16729-491; 69539-132; 72205-039; 72603-131; 69766-022; 47335-062
UNII R4Z9X1N2ND
Synonyms dofetilide | 1-(4-methanesulfonamidophenoxy)-2-(N-(4-methanesulfonamidophenethyl)-N-methylamine)ethane | 1-MSPMPE | Tikosyn | UK 68798 | UK-68,798
Chemical Information
Molecular Formula C19H27N3O5S2
CAS Registry Number 115256-11-6
SMILES CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Amnesia17.03.02.001; 19.20.01.0010.000330%
Anaphylactic reaction10.01.07.001; 24.06.03.0060.000271%
Angina pectoris02.02.02.002; 24.04.04.0020.000186%
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Anxiety19.06.02.002--
Application site reaction08.02.01.006; 12.07.01.006---
Arrhythmia02.03.02.0010.002275%-
Arthralgia15.01.02.001--
Arthropathy15.01.01.0030.000228%-
Asthenia08.01.01.001---
Asthma10.01.03.010; 22.03.01.0020.000228%-
Atrial fibrillation02.03.03.0020.003391%
Atrial flutter02.03.03.0030.000228%
Atrial tachycardia02.03.03.0040.000085%
Atrioventricular block02.03.01.002---
Back pain15.03.04.005--
Blindness06.02.10.003; 17.17.01.0030.000085%-
Bone disorder15.02.04.0040.000127%-
Bradycardia02.03.02.0020.000254%-
Bundle branch block02.03.01.009---
Burning sensation08.01.09.029; 17.02.06.0010.000719%-
Cardiac arrest02.03.04.0010.000778%
Cardiac failure02.05.01.0010.000541%
Cardiac failure congestive02.05.01.0020.000423%-
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.000313%-
Cerebral ischaemia17.08.01.005; 24.04.06.003--
Cerebrovascular accident17.08.01.007; 24.03.05.0010.000964%
Chest discomfort02.02.02.009; 08.01.08.019; 22.12.02.0020.000457%-
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.0030.001776%-
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ADReCS-Target
Drug Name ADR Term Target
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