Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Docetaxel
Drug ID BADD_D00699
Description Docetaxel is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel reversibly binds to tubulin with high affinity in a 1:1 stoichiometric ratio
Indications and Usage For the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Also used as a single agent in the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior platinum-based chemotherapy. It is also used in combination with prednisone, in the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer. Furthermore, docetaxel has uses in the treatment of gastric adenocarinoma and head and neck cancer.
Marketing Status approved; investigational
ATC Code L01CD02
DrugBank ID DB01248
KEGG ID D02165; D07866
MeSH ID D000077143
PubChem ID 148124
TTD Drug ID D0O5WP
NDC Product Code 0955-1020; 43066-001; 43598-259; 0409-0367; 70121-1222; 70700-175; 68554-0075; 43598-389; 45963-765; 72485-216; 17359-9100; 43598-610; 43598-611; 47335-895; 55150-378; 57884-3041; 57884-3042; 68083-399; 68083-400; 57884-3043; 70121-1221; 72485-214; 54893-0008; 65129-1298; 16729-267; 55150-380; 62332-678; 0143-9205; 43066-006; 68083-401; 0409-4235; 70121-1223; 43066-010; 55150-379; 66758-950; 0409-0368; 70700-174; 46708-678; 47335-323; 67457-781; 0409-0366; 65129-1141; 45963-734; 0409-0365; 70700-176; 0955-1021; 65129-1189; 66758-050; 0409-5068; 72485-215; 0955-1022; 0143-9204; 43598-258; 47335-939
UNII 15H5577CQD
Synonyms Docetaxel | Docetaxel Trihydrate | Docetaxol | Docetaxel Hydrate | Taxoltere Metro | RP 56976 | RP-56976 | RP56976 | Taxotere | Docetaxel Anhydrous | N-Debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol | N Debenzoyl N tert butoxycarbonyl 10 deacetyltaxol | NSC 628503
Chemical Information
Molecular Formula C43H53NO14
CAS Registry Number 114977-28-5
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O) O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lacrimation increased06.08.02.004--
Large intestine perforation07.04.06.005; 12.02.03.005--
Laryngeal pain22.12.03.010--
Lethargy08.01.01.008; 17.02.04.003; 19.04.04.004--
Leukopenia01.02.02.001---
Liver disorder09.01.08.001---
Liver function test abnormal13.03.04.030---
Loss of consciousness17.02.04.004---
Lower respiratory tract infection11.01.09.002; 22.07.01.002---
Lung disorder22.02.07.001---
Lymphoedema01.09.01.006; 24.09.01.001--
Lymphopenia01.02.02.002---
Malaise08.01.01.003--
Mass08.03.05.003---
Menopausal symptoms21.02.02.002---
Menstruation irregular05.05.01.008; 21.01.01.005--
Metastases to liver09.04.02.004; 16.22.02.001---
Metastases to lung16.22.02.002; 22.08.01.005---
Migraine17.14.02.001; 24.03.05.003---
Mouth ulceration07.05.06.004---
Mucosal inflammation08.01.06.002---
Muscle spasms15.05.03.004--
Myalgia15.05.02.001--
Myelodysplastic syndrome01.10.04.001; 16.01.04.001--
Myocardial infarction02.02.02.007; 24.04.04.009--
Myocardial ischaemia02.02.02.008; 24.04.04.010---
Nail discolouration23.02.05.001--
Nail disorder23.02.05.002--
Nasopharyngitis11.01.13.002; 22.07.03.002---
Nausea07.01.07.001--
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ADReCS-Target
Drug Name ADR Term Target
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