Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Disulfiram
Drug ID BADD_D00695
Description A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Indications and Usage For the treatment and management of chronic alcoholism
Marketing Status approved
ATC Code N07BB01; P03AA04
DrugBank ID DB00822
KEGG ID D00131
MeSH ID D004221
PubChem ID 3117
TTD Drug ID D0X5SD
NDC Product Code 42973-137; 71052-221; 42794-028; 0054-0357; 73309-150; 51927-3121; 62135-432; 64980-171; 0054-0356; 38779-1971; 65571-0005; 62135-431; 64980-172; 51927-0188; 72643-028; 47781-607; 60429-196
UNII TR3MLJ1UAI
Synonyms Disulfiram | Bis(diethylthiocarbamoyl) Disulfide | Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2 | Tetraethylthiuram Disulfide | Disulfide, Tetraethylthiuram | Antabus | Antabuse | Teturam | Dicupral | Esperal | Alcophobin | Anticol
Chemical Information
Molecular Formula C10H20N2S4
CAS Registry Number 97-77-8
SMILES CCN(CC)C(=S)SSC(=S)N(CC)CC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatitis09.01.07.004---
Hepatitis fulminant09.01.07.007; 11.07.01.003---
Hepatitis toxic09.01.07.017; 12.03.01.0160.003777%-
Hepatomegaly09.01.05.0010.005665%-
Hypertension24.08.02.0010.009442%
Hypoaesthesia17.02.06.023; 23.03.03.081---
Hypomania19.16.02.0010.003777%-
Hypotension24.06.03.0020.007553%
Insomnia17.15.03.002; 19.02.01.0020.007553%
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.0300.003777%-
Lethargy08.01.01.008; 17.02.04.003; 19.04.04.0040.003777%
Metabolic acidosis14.01.01.0030.005665%-
Methaemoglobinaemia01.05.01.0020.005665%
Neuritis17.09.03.001---
Neuropathy peripheral17.09.03.0030.037767%-
Neurotoxicity12.03.01.011; 17.02.10.0020.007553%-
Optic neuritis06.04.08.002; 10.02.01.097; 17.04.05.001---
Pain08.01.08.004--
Paraesthesia17.02.06.005; 23.03.03.094--
Peripheral sensory neuropathy17.09.03.0050.003777%
Peroneal nerve palsy17.09.02.0030.003777%-
Polyneuropathy17.09.03.0120.011330%-
Portal hypertension09.01.06.006; 24.08.06.0010.003777%
Rash23.03.13.001---
Seizure17.12.03.0010.003777%
Sensory loss17.02.07.007---
Somnolence17.02.04.006; 19.02.05.0030.003777%
Stress19.06.02.004---
Suicide attempt19.12.01.0040.005665%
Syncope02.11.04.015; 17.02.04.008; 24.06.02.0120.011330%
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ADReCS-Target
Drug Name ADR Term Target
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