Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Disopyramide
Drug ID BADD_D00693
Description A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
Indications and Usage For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. It is a Class Ia antiarrhythmic drug.
Marketing Status approved
ATC Code C01BA03
DrugBank ID DB00280
KEGG ID D00303
MeSH ID D004206
PubChem ID 3114
TTD Drug ID D0M4YC
NDC Product Code Not Available
UNII GFO928U8MQ
Synonyms Disopyramide | Diisopyramide | Disopyramide Phosphate | Disopyramide Phosphate (1:1) | Disopyramide Phosphate (1:1), (+-)-Isomer | Disopyramide Phosphate (1:1), (R)-Isomer | Disopyramide Phosphate (1:1), (S)-Isomer | Disopyramide, (+-)-Isomer | Disopyramide, (R)-Isomer | Disopyramide, (S)-Isomer | Disopyramide, D-Tartrate (1:1), (S)-Isomer | Disopyramide, L-Tartrate (1:1), (R)-Isomer | Disopyramide, L-Tartrate (1:1), (S)-Isomer | Disopyramide, L-Tartrate (1:2), (+-)-Isomer | Disopyramide, L-Tartrate, (S)-isomer | Norpace | Palpitin | Palpitine | Rhythmodan | Ritmilen | Rythmilen | SC-13957 | SC 13957 | SC13957 | Disopyramide Monohydrochloride
Chemical Information
Molecular Formula C21H29N3O
CAS Registry Number 3737-09-5
SMILES CC(C)N(CCC(C1=CC=CC=C1)(C2=CC=CC=N2)C(=O)N)C(C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain upper07.01.05.003--
Accommodation disorder06.02.04.001---
Acute psychosis19.03.01.001---
Agranulocytosis01.02.03.001---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Apnoea22.02.01.001--
Arrhythmia02.03.02.0010.001911%-
Asthenia08.01.01.0010.004204%-
Atrial fibrillation02.03.03.002--
Atrioventricular block02.03.01.002---
Blood creatinine increased13.13.01.004--
Blood urea increased13.13.01.006---
Body temperature increased13.15.01.001---
Bradycardia02.03.02.0020.002866%-
Bundle branch block02.03.01.009---
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.0020.001911%-
Cardiac output decreased13.14.02.001---
Cardiogenic shock02.05.01.003; 24.06.02.006---
Cerebrovascular accident17.08.01.007; 24.03.05.0010.001911%
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Coma17.02.09.001---
Condition aggravated08.01.03.004---
Confusional state17.02.03.005; 19.13.01.0010.001911%
Constipation07.02.02.001--
Cyanosis02.11.04.004; 22.02.02.007; 23.06.04.005; 24.03.01.007--
Defect conduction intraventricular02.03.01.018---
Depression19.15.01.001--
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ADReCS-Target
Drug Name ADR Term Target
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