| Pharmaceutical Information |
| Drug Name |
Dinutuximab |
| Drug ID |
BADD_D00685 |
| Description |
Dinutuximab is an IgG1 monoclonal human/mouse chimeric antibody against GD2, a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues. It is composed of the variable heavy- and light-chain regions of the murine anti-GD2 mAb 14.18 and the constant regions of human IgG1 heavy-chain and kappa light-chain. By binding to GD2, dinutiximab induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity of tumor cells thereby leading to apoptosis and inhibiting proliferation of the tumour. It is indicated, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and 13-cis-retinoic acid (RA), for the treatment of pediatric patients with high-risk neuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy. Despite a high clinical response seen after first-line treatment, the complete eradication of neuroblastoma is rarely achieved and the majority of patients with advanced disease suffer a relapse. Current strategies for treatment include immunotherapy with drugs such as dinutuximab to target surviving neuroblastoma cells and to prevent relapse. |
| Indications and Usage |
Dinutuximab is indicated, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2 (IL-2), and 13-cis-retinoic acid (RA), for the treatment of pediatric patients with high-risk neuroblastoma who achieve at least a partial response to prior first-line multiagent, multimodality therapy. Despite a high clinical response seen after first-line treatment, the complete eradication of neuroblastoma is rarely achieved and the majority of patients with advanced disease suffer a relapse. Current strategies for treatment include immunotherapy with drugs such as dinutuximab to target surviving neuroblastoma cells and to prevent relapse. |
| Marketing Status |
approved; investigational |
| ATC Code |
L01FX06 |
| DrugBank ID |
DB09077
|
| KEGG ID |
D10559
|
| MeSH ID |
C112746
|
| PubChem ID |
Not Available
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| TTD Drug ID |
Not Available
|
| NDC Product Code |
66302-014 |
| UNII |
7SQY4ZUD30
|
| Synonyms |
dinutuximab | dinutuximab beta | APN-311 | APN311 | unituxin | ch14.18 | MAb ch14.18 | CH-14.18-UTC | CH-14.18 | monoclonal antibody ch14.18 | ch14.18 monoclonal antibody | CH14.18-UTC |
|
| Chemical Information |
| Molecular Formula |
Not Available |
| CAS Registry Number |
1363687-32-4 |
| SMILES |
Not Available |
| Chemical Structure |
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| ADRs Induced by Drug |
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