| Drug Name |
Dimenhydrinate |
| Drug ID |
BADD_D00676 |
| Description |
Dimehydrinate was first described in the literature in 1949,[A233120] and patented in 1950.[L32995] Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery.[A233130]
Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyllinate, is indicated to prevent nausea, vomiting, and dizziness caused by motion sickness.[L32980,L32985,L32995] Dimenhydrinate is a combination of [Diphenhydramine] and [8-chlorotheophylline] in a salt form, with 53%-55.5% dried diphenhydramine, and 44%-47% died 8-chlorotheophylline.[L32985]
The antiemetic properties of dimenhydrinate are primarily thought to be produced by diphenhydramine's antagonism of H1 histamine receptors in the vestibular system[A1540] while the excitatory effects are thought to be produced by 8-chlorotheophylline's adenosine receptor blockade.[A33889]
When used in large doses, dimenhydrinate has been shown to cause a "high" characterized by hallucinations, excitement, incoordination, and disorientation.[A1539]
Dimenhydrinate was granted FDA approval on 31 May 1972.[L32975] |
| Indications and Usage |
Dimenhydrinate is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness.[L32980,L32985] |
| Marketing Status |
approved |
| ATC Code |
R06AA11 |
| DrugBank ID |
DB00985
|
| KEGG ID |
D00520
|
| MeSH ID |
D004111
|
| PubChem ID |
10660
|
| TTD Drug ID |
D0U8UV
|
| NDC Product Code |
10237-940; 63323-366; 70677-0022; 0904-6772; 29485-1216; 29485-6925; 63029-901; 63868-034; 12711-4675; 10237-941; 11673-198; 46122-536; 52904-962; 63029-910; 0363-1980; 10267-1006; 63029-902; 49873-802; 50844-199; 63941-198; 67751-170; 10267-4186; 49452-2615; 55745-0002; 11822-0198; 36800-930; 0363-0198; 66715-9809; 70000-0404; 70677-1087; 62011-0341; 67091-118; 0904-2051; 10267-4215; 10237-942; 49035-981; 69842-206; 29485-8048; 50804-198 |
| UNII |
JB937PER5C
|
| Synonyms |
Dimenhydrinate | Diphenhydramine Theoclate | Theoclate, Diphenhydramine | Wehamine | Aviomarin | Biodramina | Calm-X | Calm X | Cinfamar | Contramareo | Dimen Heumann | Heumann, Dimen | Dimen Lichtenstein | Lichtenstein, Dimen | Dimetabs | Dinate | DMH | Dramanate | Gravol | Marmine | Motion-Aid | Motion Aid | Nausicalm | Reisegold | Reisetabletten Lünopharm | Lünopharm, Reisetabletten | Reisetabletten Stada | Stada, Reisetabletten | Reisetabletten-ratiopharm | Reisetabletten ratiopharm | Rodovan | RubieMen | Superpep | Travel Well | TripTone | Vertigo-Vomex | Vertigo Vomex | Vomex A | Vomacur | Vomisin | Dramamine | Apo-Dimenhydrinate | Apo Dimenhydrinate |
