Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Diflunisal
Drug ID BADD_D00666
Description Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the arachidonic acid pathway. Diflunisal is used to relieve pain accompanied with inflammation and in the symptomatic treatment of rheumatoid arthritis and osteoarthritis.
Indications and Usage For symptomatic treatment of mild to moderate pain accompanied by inflammation (e.g. musculoskeletal trauma, post-dental extraction, post-episiotomy), osteoarthritis, and rheumatoid arthritis.
Marketing Status Prescription; Discontinued
ATC Code N02BA11
DrugBank ID DB00861
KEGG ID D00130
MeSH ID D004061
PubChem ID 3059
TTD Drug ID D08LFZ
NDC Product Code 42973-152; 17511-129; 70771-1083; 0093-9222; 64980-181; 68382-530; 0093-0755; 15308-0811; 14593-891; 14539-673; 49452-2597
Synonyms Diflunisal | Dolobid | Dolocid | Dolobis | Nu-Diflunisal | Nu Diflunisal | NuDiflunisal | MK-647 | MK 647 | MK647 | Novo-Diflunisal | Novo Diflunisal | NovoDiflunisal | Apo-Diflunisal | Apo Diflunisal | ApoDiflunisal
Chemical Information
Molecular Formula C13H8F2O3
CAS Registry Number 22494-42-4
SMILES C1=CC(=C(C=C1C2=C(C=C(C=C2)F)F)C(=O)O)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agranulocytosis01.02.03.001--Not Available
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Angioedema10.01.05.009; 23.04.01.001--Not Available
Asthenia08.01.01.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bronchospasm10.01.03.012; 22.03.01.004--
Cellulitis gangrenous11.02.01.016; 23.09.01.010--Not Available
Chest pain02.02.02.011; 08.01.08.002; 22.02.08.003--Not Available
Cholestasis09.01.01.001--Not Available
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Deafness04.02.01.001--Not Available
Death08.04.01.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis exfoliative10.01.01.004; 23.03.07.001--
Diarrhoea07.02.01.001--
Disorientation17.02.05.015; 19.13.01.002--Not Available
Dizziness02.01.02.004; 17.02.05.003; 24.06.02.007--
Dyspepsia07.01.02.001--
Dyspnoea02.01.03.002; 22.02.01.004--
Dysuria20.02.02.002--
Eructation07.01.02.003--
Erythema multiforme10.01.03.015; 23.03.01.003--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Flatulence07.01.04.002--
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Gastritis07.08.02.001--
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