Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Dicyclomine hydrochloride
Drug ID BADD_D00660
Description Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable.[L7982] Dicyclomine was granted FDA approval on 11 May 1950.[L7967]
Indications and Usage including Colicky abdominal pain; diverticulitis
Marketing Status Prescription; Discontinued
ATC Code A03AA07
DrugBank ID DB00804
KEGG ID D00717
MeSH ID D004025
PubChem ID 441344
TTD Drug ID D07XJM
NDC Product Code 70934-682; 61919-324; 51662-1559; 58118-1282; 70518-1767; 0904-6969; 68788-9525; 0603-1161; 68071-3310; 70934-518; 58914-080; 51655-257; 70518-3220; 70934-754; 71335-0425; 67296-1039; 0904-6988; 70436-147; 55289-923; 50090-4681; 50090-0129; 53002-3290; 68083-320; 67296-1409; 70518-1596; 71610-265; 68071-5200; 50090-5454; 63629-8049; 68788-7948; 0517-1980; 60687-369; 63187-196; 0641-6173; 50090-4553; 55700-766; 0527-0586; 50090-0126; 70518-2081; 66267-291; 70518-0302; 67296-0126; 70518-0100; 61919-904; 55700-933; 70625-103; 71335-0938; 0378-1610; 0904-6987; 71610-209; 68071-4782; 43063-045; 63323-842; 43063-629; 55154-3565; 14789-010; 53002-3291; 0054-0622; 0143-1227; 0591-0795; 17337-0015; 55154-8183; 63629-6320; 63629-3341; 63187-784; 17478-015; 50090-2185; 72266-127; 63629-2179; 68788-9705; 70954-261; 70934-649; 68071-3255; 53002-3450; 71205-428; 67296-1050; 51407-365; 31722-963; 70934-519; 50090-1577; 68071-3035; 0591-0794; 70934-182; 0143-3126; 63187-410; 60687-380; 43063-112; 67296-1741; 71335-0471; 49999-081; 68788-7811; 0527-1282; 10135-520; 60760-631; 50090-0128; 17856-0623; 71205-043; 50090-4253; 69037-0069; 50090-0127; 71335-0641; 50090-4677
Synonyms Dicyclomine | Dicycloverin | Dicyclomine Hydrochloride | Hydrochloride, Dicyclomine | Merbentyl | Bentylol | Spascol | Di-Spaz | Di Spaz | Dibent | Diclomin | Lomine | OR-Tyl | OR Tyl | Bentyl | Di-Cyclonex | Di Cyclonex
Chemical Information
Molecular Formula C19H36ClNO2
CAS Registry Number 67-92-5
SMILES CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2.Cl
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Ageusia07.14.03.003; 17.02.07.001--Not Available
Agitation17.02.05.012; 19.06.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Apnoea22.02.01.001--
Asphyxia12.01.08.011; 22.02.02.001--Not Available
Asthenia08.01.01.001--Not Available
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Cycloplegia06.05.03.002; 17.17.02.003--Not Available
Diplopia06.02.06.002; 17.17.01.005--Not Available
Dizziness02.01.02.004; 17.02.05.003; 24.06.02.007--
Dry mouth07.06.01.002--
Dyskinesia17.01.02.006--
Dyspnoea02.01.03.002; 22.02.01.004--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hypoaesthesia17.02.06.023--Not Available
Hypohidrosis08.01.03.029; 23.02.03.005--
Insomnia17.15.03.002; 19.02.01.002--
Intraocular pressure increased13.07.04.002--Not Available
Lethargy08.01.01.008; 17.02.04.003; 19.04.04.004--
Mydriasis06.05.03.004; 17.02.11.003--Not Available
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Pruritus23.03.12.001--
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