Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Dicyclomine hydrochloride
Drug ID BADD_D00660
Description Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable.[L7982] Dicyclomine was granted FDA approval on 11 May 1950.[L7967]
Indications and Usage Dicyclomine is indicated for the treatment of functional bowel disorder and irritable bowel syndrome.[L7967]
Marketing Status approved
ATC Code Not Available
DrugBank ID DB00804
KEGG ID D00717
MeSH ID D004025
PubChem ID 441344
TTD Drug ID D07XJM
NDC Product Code 0904-6987; 58118-1282; 59651-720; 0517-1980; 0527-0586; 70518-0302; 0603-1161; 72888-119; 0143-1227; 51407-783; 55700-933; 61919-904; 67296-1741; 68788-8373; 70934-519; 0591-0794; 0641-6173; 0832-6053; 42708-160; 43063-045; 63629-3341; 67296-0126; 68788-7811; 70518-1767; 63629-8049; 70934-682; 0591-0795; 82982-029; 24979-200; 43063-629; 55154-3565; 59651-719; 60760-638; 61919-324; 68083-320; 68788-9525; 0527-1282; 70518-0327; 70518-0755; 70518-3220; 70934-649; 71205-043; 71205-428; 71610-265; 17337-0015; 24979-201; 50090-4253; 51655-219; 60687-380; 67296-1039; 67296-1050; 71610-209; 0904-6988; 50090-0126; 50090-1577; 51655-257; 58914-080; 60687-369; 70436-147; 71335-0641; 71335-9709; 72162-1077; 72266-127; 69037-0069; 17478-015; 49999-291; 50090-0127; 50090-5454; 51407-365; 51662-1559; 63629-2179; 66267-291; 68071-2868; 71335-0471; 71335-0938; 0615-0327; 14789-010; 0143-3126; 49999-081; 50090-4553; 51655-940; 53002-3290; 53002-3451; 55154-8183; 63187-196; 63187-784; 68071-5200; 0054-0622; 70954-261; 71335-0425; 43063-112; 53002-3291; 53002-3450; 55289-923; 62135-428; 63187-410; 63323-842; 68788-9705; 0054-0748; 70934-757; 0832-6052; 17856-0623; 55700-766
UNII CQ903KQA31
Synonyms Dicyclomine | Dicycloverin | Dicyclomine Hydrochloride | Hydrochloride, Dicyclomine | Merbentyl | Bentylol | Spascol | Di-Spaz | Di Spaz | Dibent | Diclomin | Lomine | OR-Tyl | OR Tyl | Bentyl | Di-Cyclonex | Di Cyclonex
Chemical Information
Molecular Formula C19H36ClNO2
CAS Registry Number 67-92-5
SMILES CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Ageusia07.14.03.003; 17.02.07.001---
Agitation17.02.05.012; 19.06.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Apnoea22.02.01.001--
Asphyxia12.01.08.011; 22.02.02.001---
Asthenia08.01.01.001---
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Cycloplegia06.05.03.002; 17.17.02.003---
Diplopia06.02.06.002; 17.17.01.005---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dry mouth07.06.01.002--
Dyskinesia17.01.02.006--
Dyspnoea02.11.05.003; 22.02.01.004--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hypoaesthesia17.02.06.023; 23.03.03.081---
Hypohidrosis08.01.03.029; 23.02.03.005--
Insomnia17.15.03.002; 19.02.01.002--
Intraocular pressure increased13.07.04.002---
Lethargy08.01.01.008; 17.02.04.003; 19.04.04.004--
Mydriasis06.05.03.004; 17.02.11.003---
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Nervousness19.06.02.003---
Palpitations02.11.04.012--
Paraesthesia17.02.06.005; 23.03.03.094--
Pruritus23.03.12.001--
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