Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Desvenlafaxine
Drug ID BADD_D00621
Description Desvenlafaxine (O-desmethylvenlafaxine) the major active metabolite of venlafaxine, is an antidepressant from the serotonin norepinephrine reuptake inhibitor (SNRI) class[Label]. Desvenlafaxine may be used to treat major depressive disorder[Label]. It is formulated as an extended release tablet[Label]. Desvenlafaxine was approved by the FDA in 2008[L6016].
Indications and Usage Desvenlafaxine is indicated for the treatment of major depressive disorder in adults.
Marketing Status Prescription; Discontinued
ATC Code N06AX23
DrugBank ID DB06700
KEGG ID D07793
MeSH ID D000069468
PubChem ID 125017
TTD Drug ID D0O3FG
NDC Product Code 70436-012; 70436-013; 50090-4806; 0054-0401; 46708-152; 70518-3195; 68382-469; 0591-3659; 71335-1815; 0054-0603; 70436-036; 71335-1753; 51407-023; 0591-4060; 50090-4388; 63304-191; 0591-3660; 14501-0068; 46708-153; 60687-607; 70771-1311; 68382-741; 71335-1975; 0054-0400; 51407-022; 63304-192; 63629-7524; 71335-1700; 70771-1312; 69766-025
Synonyms Desvenlafaxine Succinate | Succinate, Desvenlafaxine | O-desmethylvenlafaxine Succinate Monohydrate | Monohydrate, O-desmethylvenlafaxine Succinate | O desmethylvenlafaxine Succinate Monohydrate | Succinate Monohydrate, O-desmethylvenlafaxine | 2-(1-hydroxycyclohexyl)-2-((4-hydroxyphenyl)ethyl)dimethylammonium 3-carboxypropanoate monohydrate | O-desmethylvenlafaxine Succinate | O desmethylvenlafaxine Succinate | Succinate, O-desmethylvenlafaxine | WY 45,233 | 45,233, WY | WY-45,233 | WY45,233 | WY-45233 | WY45233 | WY 45233 | 45233, WY | Pristiq | Desvenlafaxine | O-desmethylvenlafaxine | O desmethylvenlafaxine | 4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol
Chemical Information
Molecular Formula C16H25NO2
CAS Registry Number 93413-62-8
SMILES CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams17.15.02.001; 19.02.03.0010.003807%Not Available
Aggression19.05.01.0010.003384%Not Available
Agitation17.02.05.012; 19.06.02.0010.009729%
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.0010.003384%
Amnesia17.03.02.001; 19.20.01.0010.003807%
Anaemia01.03.02.001--
Anger19.04.02.0010.005499%Not Available
Angioedema10.01.05.009; 23.04.01.001--Not Available
Angle closure glaucoma06.03.01.001--Not Available
Anorgasmia19.08.01.0010.000846%
Anxiety19.06.02.0020.014804%
Apathy19.04.04.0020.000846%Not Available
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Arthropathy15.01.01.0030.000846%Not Available
Asthenia08.01.01.0010.006768%Not Available
Back pain15.03.04.005--
Blindness06.02.02.001; 17.17.01.0030.000846%Not Available
Blister12.01.06.002; 23.03.01.001--Not Available
Blood cholesterol13.12.01.014--Not Available
Blood cholesterol increased13.12.01.0020.001692%
Blood glucose increased13.02.02.0020.001269%Not Available
Blood pressure increased13.14.03.0050.008883%Not Available
Blood prolactin increased13.10.03.0020.000846%Not Available
Blood triglycerides13.12.03.004--Not Available
Blood triglycerides increased13.12.03.001--Not Available
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