Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Demeclocycline
Drug ID BADD_D00605
Description A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Indications and Usage Used primarily to treat Lyme disease, acne, and bronchitis. Also indicated (but rarely used) to treat urinary tract infections, gum disease, malaria, and other bacterial infections such as gonorrhea and chlamydia. One of its other registered uses is the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective.
Marketing Status approved
ATC Code D06AA01; J01AA01
DrugBank ID DB00618
KEGG ID D03680
MeSH ID D003707
PubChem ID 54680690
TTD Drug ID D0R9WP
NDC Product Code 53746-554; 60687-691; 65162-555; 53746-555; 60687-705; 65162-554
UNII 5R5W9ICI6O
Synonyms Demeclocycline | Demethylchlortetracycline | Declomycin | Lédermycine | Ledermycin | Demeclocycline, Calcium (1:1) Salt | Demeclocycline Monohydrochloride | Monohydrochloride, Demeclocycline | Demeclocycline, 4-epimer | Demeclocycline, Calcium (1:2) Salt | Demeclocycline Hydrochloride | Hydrochloride, Demeclocycline
Chemical Information
Molecular Formula C21H21ClN2O8
CAS Registry Number 127-33-3
SMILES CN(C)C1C2CC3C(C4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Heavy menstrual bleeding21.01.03.005---
Idiopathic intracranial hypertension17.07.02.011---
The 3th Page    First    Pre   3    Total 3 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene