Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Deferiprone
Drug ID BADD_D00595
Description Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA approved on October 14, 2011.
Indications and Usage Deferiprone is indicated in thalassemia syndromes when first line chelation agents are not adequate to treat transfusional iron overload.
Marketing Status approved
ATC Code V03AC02
DrugBank ID DB08826
KEGG ID D07416
MeSH ID D000077543
PubChem ID 2972
TTD Drug ID D0N0OU
NDC Product Code 17349-0023; 10122-103; 0054-0711; 10122-100; 51672-4196; 10122-104; 10122-101; 0054-0576; 52609-4502
UNII 2BTY8KH53L
Synonyms Deferiprone | 1,2-Dimethyl-3-hydroxy-4-pyridinone | 1,2 Dimethyl 3 hydroxy 4 pyridinone | DMOHPO | 1,2-Dimethyl-3-hydroxypyrid-4-one | 1,2 Dimethyl 3 hydroxypyrid 4 one | 3-Hydroxy-1,2-dimethyl-4-pyridinone | 3 Hydroxy 1,2 dimethyl 4 pyridinone | HDMPP | 1,2-Dimethyl-3-hydroxypyridin-4-one | 1,2 Dimethyl 3 hydroxypyridin 4 one | Ferriprox
Chemical Information
Molecular Formula C7H9NO2
CAS Registry Number 30652-11-0
SMILES CC1=C(C(=O)C=CN1C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neutrophil count decreased13.01.06.010--
Nystagmus06.05.02.006; 17.02.02.006--
Obsessive-compulsive disorder19.06.05.002---
Oedema08.01.07.006; 14.05.06.0100.001239%-
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Optic neuritis06.04.08.002; 10.02.01.097; 17.04.05.001---
Osteoarthritis15.01.04.001---
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.003---
Papilloedema06.09.02.002; 17.07.02.004; 24.03.07.001--
Parotid gland enlargement07.06.03.001---
Periorbital oedema06.08.03.017; 10.01.05.010; 23.04.01.002--
Pharyngitis07.05.07.004; 11.01.13.003; 22.07.03.004--
Photosensitivity reaction23.03.09.003--
Pneumonia11.01.09.003; 22.07.01.003---
Pruritus23.03.12.001--
Pulmonary embolism22.06.02.001; 24.01.06.001---
Pyrexia08.05.02.0030.013506%
Rash23.03.13.001---
Rash pustular11.01.12.002; 23.03.10.003--
Rectal haemorrhage07.12.03.001; 24.07.02.018--
Seizure17.12.03.001--
Sepsis11.01.11.003--
Sickle cell anaemia with crisis01.04.02.0010.003717%-
Skin disorder23.03.03.007---
Somnolence17.02.04.006; 19.02.05.0030.001859%
Subcutaneous abscess11.01.12.007; 23.11.04.008---
Tachycardia02.03.02.0070.001859%-
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