Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dasatinib
Drug ID BADD_D00589
Description Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.
Indications and Usage For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.
Marketing Status Prescription
ATC Code L01EA02
DrugBank ID DB01254
KEGG ID D03658
MeSH ID D000069439
PubChem ID 3062316
TTD Drug ID D0E6XR
NDC Product Code 63285-862; 63285-867; 0003-0855; 63285-863; 63285-866; 63285-865; 68554-0070; 54893-0015; 54893-0047; 0003-0857; 0003-0852; 0003-0527; 0003-0528; 76302-014; 50193-0524; 46708-891; 14778-1313; 62207-973; 63285-864; 0003-0524; 59651-468; 53104-7725
Synonyms Dasatinib | N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | Sprycel | (18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | BMS 354825 | 354825, BMS | BMS354825 | BMS-354825
Chemical Information
Molecular Formula C22H26ClN7O2S
CAS Registry Number 302962-49-8
SMILES CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dry eye06.08.02.0010.002131%
Dry mouth07.06.01.002--
Dry skin23.03.03.0010.006127%
Dysgeusia07.14.03.001; 17.02.07.0030.006127%
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dysphonia17.02.08.004; 19.19.03.002; 22.02.05.005--
Dyspnoea02.01.03.002; 22.02.01.0040.054614%
Dyspnoea exertional02.01.03.003; 22.02.01.0050.004795%Not Available
Dysuria20.02.02.002--
Ear disorder04.03.01.001--Not Available
Ear haemorrhage04.03.01.002; 24.07.01.004--Not Available
Ear infection04.03.01.006; 11.01.05.0010.001865%Not Available
Ear pain04.03.01.0030.001066%
Eating disorder14.03.01.008; 19.09.01.008--Not Available
Ecchymosis01.01.03.001; 23.06.01.001; 24.07.06.002--Not Available
Eczema23.03.04.006--
Electrocardiogram13.14.05.037--Not Available
Electrocardiogram abnormal13.14.05.0010.001332%Not Available
Electrocardiogram QT prolonged13.14.05.0040.004529%
Electrolyte imbalance14.05.01.0020.000799%Not Available
Emotional disorder19.04.02.005--Not Available
Emphysema22.01.02.0020.000278%Not Available
Empyema11.01.08.0200.000533%Not Available
Encephalitis11.01.03.008; 17.06.05.0010.000533%
Encephalopathy17.13.02.001--
Endocarditis02.09.01.001; 11.01.16.0010.000278%
Enteritis07.08.03.0020.001332%
Enterocolitis07.08.03.0030.002398%
Enterocolitis haemorrhagic07.08.01.007; 24.07.02.0060.005861%Not Available
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ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene