Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dapsone
Drug ID BADD_D00580
Description A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Indications and Usage For the treatment and management of leprosy and dermatitis herpetiformis.
Marketing Status approved; investigational
ATC Code D10AX05; J04BA02
DrugBank ID DB00250
KEGG ID D00592
MeSH ID D003622
PubChem ID 2955
TTD Drug ID D0MA9N
NDC Product Code 0023-5206; 29967-0007; 16110-526; 49938-102; 51672-4197; 68308-342; 51927-0085; 53596-014; 13668-605; 70954-135; 0713-0886; 16714-956; 51552-1042; 29033-036; 49938-101; 60429-495; 0378-4830; 14474-038; 50218-008; 51927-0083; 73309-094; 51672-1387; 71052-100; 72375-0006; 16110-367; 29033-037; 43353-222; 51672-1388; 60429-496; 60758-670; 70954-136; 10695-047; 51927-0084; 51672-4198; 46438-0645; 49452-2439; 65571-0021; 76072-1018; 64980-566; 14474-026; 45562-1120; 51927-4368; 58159-033; 43353-223; 0023-3670
UNII 8W5C518302
Synonyms Dapsone | DADPS | Sulfonyldianiline | Diaminodiphenylsulfone | Diaphenylsulfone | 4,4'-Diaminophenyl Sulfone | 4,4' Diaminophenyl Sulfone | Sulfone, 4,4'-Diaminophenyl | Sulfona | Dapson-Fatol | Disulone | Avlosulfone | Dapsoderm-X
Chemical Information
Molecular Formula C12H12N2O2S
CAS Registry Number 80-08-0
SMILES C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.001723%
Acne23.02.01.0010.007480%-
Acute hepatic failure09.01.03.0010.001100%-
Acute respiratory failure14.01.04.004; 22.02.06.0010.000917%-
Agitation17.02.05.012; 19.06.02.0010.000990%
Agranulocytosis01.02.03.0010.002017%-
Albuminuria20.02.01.001---
Anaemia01.03.02.0010.003263%
Anoxia22.02.02.009---
Anuria20.01.03.0020.000367%-
Application site erythema08.02.01.001; 12.07.01.001; 23.03.06.0050.003300%-
Application site irritation08.02.01.003; 12.07.01.0030.001247%-
Application site pain08.02.01.004; 12.07.01.0040.004363%-
Application site pruritus08.02.01.005; 12.07.01.005; 23.03.12.0040.001247%-
Application site reaction08.02.01.006; 12.07.01.006---
Ascites02.05.04.002; 07.07.01.001; 09.01.05.0030.000733%
Asthenia08.01.01.001---
Atelectasis22.01.02.0010.000367%
Blister12.01.06.002; 23.03.01.0010.001540%-
Body temperature increased13.15.01.001---
Bradycardia02.03.02.0020.000367%-
Burning sensation08.01.09.029; 17.02.06.0010.005170%-
Cardiac arrest02.03.04.0010.000550%
Cardiac failure congestive02.05.01.0020.000367%-
Cerebral infarction17.08.01.004; 24.04.06.0020.000367%-
Chest discomfort02.02.02.009; 08.01.08.019; 22.12.02.0020.000367%-
Chills08.01.09.001; 15.05.03.0160.000733%
Cholestasis09.01.01.0010.000550%-
Coagulopathy01.01.02.0010.000367%-
Coma17.02.09.0010.000367%-
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ADReCS-Target
Drug Name ADR Term Target
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