Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Danazol
Drug ID BADD_D00576
Description A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Indications and Usage For the treatment of endometriosis and fibrocystic breast disease (in patients unresponsive to simple measures). Also used for the prophylactic treatment of all types of hereditary angioedema in males and females.
Marketing Status approved
ATC Code G03XA01
DrugBank ID DB01406
KEGG ID D00289
MeSH ID D003613
PubChem ID 28417
TTD Drug ID D09IPV
NDC Product Code 38779-0174; 0555-0635; 0555-0633; 62135-477; 0527-1369; 71205-862; 0527-1392; 53104-7501; 71052-662; 62135-476; 62135-475; 0527-1368; 49452-2436; 71205-861; 49076-5201; 0555-0634
UNII N29QWW3BUO
Synonyms Danazol | Danazant | Panacrine | Danocrine | Ladogal | Cyclomen | Danatrol | Danol | Danoval | Norciden | Azol | Danazol-Ratiopharm | Danazol Ratiopharm
Chemical Information
Molecular Formula C22H27NO2
CAS Registry Number 17230-88-5
SMILES CC12CCC3C(C1CCC2(C#C)O)CCC4=CC5=C(CC34C)C=NO5
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.003541%
Abdominal pain upper07.01.05.003--
Acne23.02.01.001---
Acute myeloid leukaemia01.10.05.001; 16.01.05.0010.002361%-
Alopecia23.02.02.001--
Amenorrhoea05.05.01.002; 21.01.02.001--
Anaemia01.03.02.0010.002361%
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.0010.002361%-
Anxiety19.06.02.0020.002361%
Arterial thrombosis24.01.01.002---
Arthralgia15.01.02.001--
Asthenia08.01.01.0010.003541%-
Back pain15.03.04.005--
Bartholin's cyst16.04.04.003; 21.08.03.001---
Blood creatine phosphokinase abnormal13.04.01.002---
Blood glucagon abnormal13.10.02.009---
Blood insulin increased13.10.02.001---
Blood pressure increased13.14.03.005---
Body temperature increased13.15.01.001---
Breast atrophy21.05.04.005--
Breast discharge21.05.05.001---
Carpal tunnel syndrome17.09.02.001---
Cataract06.06.01.001--
Cataract subcapsular06.06.01.002---
Chills08.01.09.001; 15.05.03.016--
Chromaturia20.02.01.0020.002361%
Cold sweat08.01.03.024; 23.02.03.0020.002361%-
Constipation07.02.02.001--
Death08.04.01.0010.004722%
Depression19.15.01.001--
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ADReCS-Target
Drug Name ADR Term Target
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