Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dalfampridine
Drug ID BADD_D00574
Description Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. FDA approved on January 22, 2010.
Indications and Usage Dalfampridine is a neurofunctional modifier that helps improve walking speed in patients with multiple sclerosis (MS).
Marketing Status approved
ATC Code N07XX07
DrugBank ID DB06637
KEGG ID D04127
MeSH ID D015761
PubChem ID 1727
TTD Drug ID D08YIN
NDC Product Code 10144-427; 63190-0510; 67877-444; 56125-427; 0591-2533; 65862-917; 62756-429; 63629-9450; 65862-863; 38779-3205; 42571-338; 51927-5030; 42571-275; 0378-4504; 12817-054; 46016-5042; 54382-125; 62756-038; 62991-3143; 65372-1157; 16729-292; 63190-0530; 51407-246; 0054-0479
UNII BH3B64OKL9
Synonyms 4-Aminopyridine | 4 Aminopyridine | Dalfampridine | Pymadine | VMI-103 | VMI 103 | VMI103 | 4-Aminopyridine Sustained Release | 4 Aminopyridine Sustained Release | Sustained Release, 4-Aminopyridine | Fampridine-SR | Fampridine SR
Chemical Information
Molecular Formula C5H6N2
CAS Registry Number 504-24-5
SMILES C1=CN=CC=C1N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cerebral disorder17.02.10.0170.001184%-
Vulvovaginal pruritus21.08.02.004; 23.03.12.0090.001830%-
Colitis microscopic07.08.01.0110.001184%-
Temperature intolerance08.01.09.0220.002746%-
Urine odour abnormal20.02.01.0200.009313%-
Paraesthesia oral07.05.05.035; 17.02.06.0080.001830%-
Cognitive disorder17.03.03.003; 19.21.02.0010.008129%
Dysgraphia17.02.03.0060.017927%-
Restless legs syndrome15.05.03.012; 17.02.07.0080.002100%-
Angiopathy24.03.02.007---
Adverse event08.06.01.0100.023956%-
Bladder disorder20.03.01.0020.005491%-
Connective tissue disorder10.04.04.026; 15.06.01.006---
Infestation11.09.01.001; 23.11.01.002---
Limb discomfort15.03.04.0140.006676%-
Mediastinal disorder22.09.03.001---
Mental disorder19.07.01.002---
Motor dysfunction15.05.06.006; 17.01.02.0310.004576%-
Spinal cord disorder17.10.01.0100.000538%-
White blood cell disorder01.02.05.0020.001830%-
Ill-defined disorder08.01.03.0490.008775%-
Urinary tract obstruction20.08.01.0040.000538%
Adverse drug reaction08.06.01.0090.060833%-
Autoimmune disorder10.04.04.0030.000538%
Renal impairment20.01.03.0100.013889%-
Poor quality sleep17.15.04.002; 19.02.05.0050.002100%-
Urethritis noninfective20.07.02.0020.000538%-
Facial spasm17.04.03.0100.001184%-
Head titubation17.01.06.0060.001184%-
Adverse reaction08.06.01.0180.003015%-
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