Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dalfampridine
Drug ID BADD_D00574
Description Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. This is the first drug that was specifically approved to help with mobility in these patients. FDA approved on January 22, 2010.
Indications and Usage Dalfampridine is a neurofunctional modifier that helps improve walking speed in patients with multiple sclerosis (MS).
Marketing Status approved
ATC Code N07XX07
DrugBank ID DB06637
KEGG ID D04127
MeSH ID D015761
PubChem ID 1727
TTD Drug ID D08YIN
NDC Product Code 10144-427; 63190-0510; 67877-444; 56125-427; 0591-2533; 65862-917; 62756-429; 63629-9450; 65862-863; 38779-3205; 42571-338; 51927-5030; 42571-275; 0378-4504; 12817-054; 46016-5042; 54382-125; 62756-038; 62991-3143; 65372-1157; 16729-292; 63190-0530; 51407-246; 0054-0479
UNII BH3B64OKL9
Synonyms 4-Aminopyridine | 4 Aminopyridine | Dalfampridine | Pymadine | VMI-103 | VMI 103 | VMI103 | 4-Aminopyridine Sustained Release | 4 Aminopyridine Sustained Release | Sustained Release, 4-Aminopyridine | Fampridine-SR | Fampridine SR
Chemical Information
Molecular Formula C5H6N2
CAS Registry Number 504-24-5
SMILES C1=CN=CC=C1N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Insomnia17.15.03.002; 19.02.01.0020.121182%
Lactose intolerance07.17.01.003; 14.02.02.0010.001830%-
Laryngeal pain22.12.03.010--
Loss of consciousness17.02.04.0040.005760%-
Lymphoedema01.09.01.006; 24.09.01.0010.001830%
Malaise08.01.01.0030.054481%
Mass08.03.05.0030.003015%-
Memory impairment17.03.02.003; 19.20.01.0030.032247%
Mental impairment17.03.03.002; 19.21.02.0030.003015%-
Metastases to lung16.22.02.002; 22.08.01.0050.000538%-
Micturition urgency20.02.02.0060.011144%
Middle insomnia17.15.03.003; 19.02.01.0030.003930%-
Migraine17.14.02.001; 24.03.05.0030.007214%-
Movement disorder17.01.02.0100.012220%-
Multiple sclerosis10.04.10.008; 17.16.01.0010.051358%-
Muscle spasms15.05.03.0040.036931%
Muscle spasticity15.05.04.011; 17.05.03.0070.010875%
Muscle twitching15.05.03.0050.003661%-
Muscular weakness15.05.06.001; 17.05.03.0050.062502%
Musculoskeletal pain15.03.04.0070.007860%
Myasthenia gravis10.04.05.001; 15.05.08.001; 17.05.04.0010.000538%
Myelopathy17.10.01.0070.001184%-
Nail discolouration23.02.05.0010.001184%
Nasopharyngitis11.01.13.002; 22.07.03.002---
Nausea07.01.07.001--
Neck pain15.03.04.0090.009583%
Neoplasm skin16.03.02.003; 23.08.02.0030.001184%-
Nephrolithiasis20.04.01.0020.002907%
Nerve compression12.01.12.001; 17.09.02.0020.002100%-
Nervous system disorder17.02.10.001---
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