ADReCS

Pharmaceutical Information

Drug Name	Dabigatran
Drug ID	BADD_D00563
Description	Dabigatran is the active form of the orally bioavailable prodrug [dabigatran etexilate].
Indications and Usage	Not Available
Marketing Status	approved; investigational
ATC Code	B01AE07
DrugBank ID	DB14726
KEGG ID	D09707
MeSH ID	D000069604
PubChem ID	216210
TTD Drug ID	D0M7JT
NDC Product Code	51869-0030
UNII	I0VM4M70GC
Synonyms	Dabigatran \| N-((2-(((4-(aminoiminomethyl)phenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)-N-2-pyridinyl-beta-alanine \| BIBR 1048 \| Pradaxa \| Dabigatran Etexilate \| Etexilate, Dabigatran \| Dabigatran Etexilate Mesylate \| Etexilate Mesylate, Dabigatran \| Mesylate, Dabigatran Etexilate

Chemical Information

Molecular Formula	C25H25N7O3
CAS Registry Number	211914-51-1
SMILES	CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Peptic ulcer	07.04.07.001	0.000905%		-
Pericardial effusion	02.06.01.002	0.019206%
Pericardial haemorrhage	02.06.01.003; 24.07.01.013	0.010545%		-
Pericarditis	02.06.02.001	0.001884%
Peripheral ischaemia	24.04.03.002	0.004159%
Petechiae	01.01.03.002; 23.06.01.003; 24.07.06.004	0.003915%		-
Pharyngeal haemorrhage	22.04.05.002; 24.07.02.017	0.000612%
Pharyngeal ulceration	22.04.05.004	0.000245%		-
Phlebitis	12.02.01.002; 24.12.03.004	0.002985%
Phlebitis superficial	24.12.03.005	0.000954%		-
Pleural effusion	22.05.02.002	0.007511%
Pleuritic pain	22.12.01.007	0.000245%
Pneumothorax	22.05.02.003	0.003548%
Polymyalgia rheumatica	10.04.05.003; 15.06.01.001	0.000367%		-
Portal vein thrombosis	09.01.06.007; 24.01.03.003	0.000612%
Proctalgia	07.03.02.001	0.002031%
Proctitis	07.08.04.001	0.001615%
Pruritus	23.03.12.001	-	-
Pulmonary alveolar haemorrhage	22.01.02.005; 24.07.01.015	0.002202%		-
Pulmonary congestion	02.05.02.002; 22.01.03.002; 24.03.08.001	0.001101%		-
Pulmonary embolism	22.06.02.001; 24.01.06.001	0.058595%		-
Pulmonary haemorrhage	22.12.01.009; 24.07.01.016	0.007707%
Pulmonary infarction	22.06.02.002; 24.04.09.001	0.000612%		-
Pulmonary oedema	02.05.02.003; 22.01.03.003	0.004771%
Pupillary disorder	06.05.03.008; 17.02.11.006	0.000245%		-
Quadriplegia	17.01.04.013	0.000856%		-
Rash	23.03.13.001	-	-	-
Rebound effect	08.06.02.009	0.000979%		-
Rectal cancer	07.21.05.002; 16.13.01.003	0.001713%		-
Rectal haemorrhage	07.12.03.001; 24.07.02.018	0.054338%

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