Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Dabigatran
Drug ID BADD_D00563
Description Dabigatran is the active form of the orally bioavailable prodrug [dabigatran etexilate].
Indications and Usage Not Available
Marketing Status approved; investigational
ATC Code B01AE07
DrugBank ID DB14726
KEGG ID D09707
MeSH ID D000069604
PubChem ID 216210
TTD Drug ID D0M7JT
NDC Product Code 51869-0030
UNII I0VM4M70GC
Synonyms Dabigatran | N-((2-(((4-(aminoiminomethyl)phenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)-N-2-pyridinyl-beta-alanine | BIBR 1048 | Pradaxa | Dabigatran Etexilate | Etexilate, Dabigatran | Dabigatran Etexilate Mesylate | Etexilate Mesylate, Dabigatran | Mesylate, Dabigatran Etexilate
Chemical Information
Molecular Formula C25H25N7O3
CAS Registry Number 211914-51-1
SMILES CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intra-abdominal haematoma07.12.02.005; 24.07.02.0340.000734%-
Gaze palsy06.05.02.014; 17.02.05.0440.000489%-
Gastrointestinal ulcer haemorrhage07.04.04.006; 24.07.02.0230.000367%-
Rectal tenesmus07.03.03.001; 15.05.03.0110.000367%-
Urine odour abnormal20.02.01.0200.000905%-
Vascular dementia17.03.01.003; 19.20.04.001; 24.04.06.0170.000245%-
Pulseless electrical activity02.03.04.0200.001346%-
Retroperitoneal haematoma07.07.02.005; 24.07.01.0600.001713%-
Hypoperfusion24.06.02.0190.000367%-
Aortic disorder24.03.04.0040.000245%-
Venous occlusion24.04.02.0090.000245%-
Intestinal mass07.11.01.0100.000489%-
Intestinal haemorrhage07.12.03.005; 24.07.02.0310.008441%-
Angiopathy24.03.02.0070.000489%-
Extremity necrosis24.04.03.0120.000367%-
Ischaemic cerebral infarction17.08.01.022; 24.04.06.0130.001590%-
Aortic rupture12.01.11.007; 24.03.04.0090.000489%-
General symptom08.01.03.0210.000245%-
Abdominal neoplasm07.21.04.001; 16.16.02.0020.000245%-
Allergic oedema08.01.07.014; 10.01.03.025---
Abdominal hernia07.16.06.0050.000538%-
Biliary tract disorder09.02.03.0010.000367%-
Brain neoplasm16.30.01.003; 17.20.01.0030.001346%-
Colon neoplasm07.21.10.001; 16.13.02.0010.001884%-
Embolism24.01.01.0090.013823%
Gastrointestinal neoplasm07.21.04.002; 16.13.11.0010.000979%-
Infarction24.04.02.0170.003963%-
Intra-abdominal haemorrhage07.12.02.008; 12.01.17.011; 24.07.02.0350.003548%
Ischaemia24.04.02.0040.004453%-
Ischaemic stroke17.08.01.018; 24.04.06.0100.157437%-
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