Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cortisone
Drug ID BADD_D00532
Description A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite hydrocortisone. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
Indications and Usage Not Available
Marketing Status experimental
ATC Code H02AB10; S01BA03
DrugBank ID DB14681
KEGG ID D07749
MeSH ID D003348
PubChem ID 222786
TTD Drug ID D0IX6I
NDC Product Code Not Available
UNII V27W9254FZ
Synonyms Cortisone | Cortisone Acetate | 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate | Cortone Acetate | Adreson
Chemical Information
Molecular Formula C21H28O5
CAS Registry Number 53-06-5
SMILES CC12CCC(=O)C=C1CCC3C2C(=O)CC4(C3CCC4(C(=O)CO)O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Alanine aminotransferase increased13.03.04.005--
Alkalosis hypokalaemic14.01.02.002---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Carbohydrate tolerance decreased13.02.02.003---
Cardiac failure congestive02.05.01.002---
Cataract subcapsular06.06.01.002---
Diabetes mellitus05.06.01.001; 14.06.01.001---
Discomfort08.01.08.003---
Ecchymosis01.01.03.001; 23.06.01.001; 24.07.06.002---
Embolism venous24.01.01.003---
Erythema23.03.06.001---
Exophthalmos05.02.02.002; 06.09.04.001---
Feeling abnormal08.01.09.014---
Fluid retention14.05.06.002; 20.01.02.003---
Glaucoma06.03.01.002--
Glucose tolerance impaired05.06.02.001; 14.06.02.001--
Haemoglobin13.01.05.018---
Headache17.14.01.001--
Hirsutism05.05.01.005; 23.02.04.001--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypernatraemia14.05.04.001--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Impaired healing08.03.02.001---
Increased appetite08.01.09.027; 14.03.01.003---
Increased insulin requirement05.06.01.006; 14.06.01.006---
Inflammatory bowel disease07.08.01.016---
Injury12.01.08.004---
Intracranial pressure increased17.07.02.002---
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