Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Corticotropin
Drug ID BADD_D00531
Description Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.
Indications and Usage Hellman P, Linder F, Hennings J, Hessman O, Eriksson B, Orlefors H, Akerstrom G: Bilateral adrenalectomy for ectopic Cushing's syndrome-discussions on technique and indication. World J Surg. 2006 May;30(5):909-16.
Marketing Status Prescription; Discontinued
ATC Code H01AA01
DrugBank ID DB01285
KEGG ID D00146
MeSH ID D000324
PubChem ID 16132265
TTD Drug ID D0R4HQ
NDC Product Code 61200-004; 38779-1904; 59149-005; 63474-200
Synonyms Adrenocorticotropic Hormone | Hormone, Adrenocorticotropic | ACTH (1-39) | ACTH | Corticotrophin | Corticotropin | Corticotropin (1-39) | Corticotrophin (1-39) | Adrenocorticotrophic Hormone | Hormone, Adrenocorticotrophic | 1-39 ACTH | Adrenocorticotropin
Chemical Information
Molecular Formula C207H308N56O58S
CAS Registry Number 9002-60-2
SMILES CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C2CCCN2C(=O)C(CC3=CC= CC=C3)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCC(=O)O)NC(=O)C(C C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CC(=O)N)NC(=O)C4CCCN4C(=O)C(CC5 =CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCCN)NC(=O)C(C(C)C)NC(=O)C6CCCN6C(=O)C(CCCNC (=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(C(C)C)NC(=O) C7CCCN7C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC8=CNC9=CC=CC=C98)NC(=O)C(CCCNC(=N)N)NC(=O)C (CC1=CC=CC=C1)NC(=O)C(CC1=CN=CN1)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O) C(CC1=CC=C(C=C1)O)NC(=O)C(CO)N
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abscess11.01.08.001--Not Available
Acne23.02.01.001--Not Available
Alkalosis hypokalaemic14.01.02.002--Not Available
Benign intracranial hypertension17.07.02.001--Not Available
Body temperature increased13.15.01.001--Not Available
Brain compression17.07.02.005--Not Available
Carbohydrate tolerance decreased13.02.02.003--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiac hypertrophy02.04.02.017--Not Available
Constipation07.02.02.001--
Cushingoid05.01.01.002; 14.11.01.006; 19.07.03.001; 24.08.02.004--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness02.01.02.004; 17.02.05.003; 24.06.02.007--
Ecchymosis01.01.03.001; 23.06.01.001; 24.07.06.002--Not Available
Endocrine disorder05.09.01.001--Not Available
Erythema23.03.06.001--Not Available
Exophthalmos05.02.02.002; 06.09.04.001--Not Available
Fluid retention14.05.06.002; 20.01.02.003--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Haemorrhage intracranial17.08.01.008; 24.07.04.003--
Headache17.14.01.001--
Hirsutism05.05.01.005; 23.02.04.001--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Impaired healing08.03.02.001--Not Available
Increased appetite08.01.09.027; 14.03.01.003--Not Available
Infection11.01.08.002--Not Available
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