Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Colistimethate sodium
Drug ID BADD_D00524
Description Colistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms. Colistimethate is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa.
Indications and Usage For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly _Pseudomonas aeruginosa_.
Marketing Status approved; vet_approved
ATC Code Not Available
DrugBank ID DB01111
KEGG ID D02049
MeSH ID C004691
PubChem ID 216258
TTD Drug ID D0Q3BV
NDC Product Code 24507-005; 63323-393; 42023-131; 63552-010; 23155-193; 45932-0016; 45932-0053; 70594-023; 14789-201; 42513-0007; 45932-0015
UNII XW0E5YS77G
Synonyms colistinmethanesulfonic acid | colistimethate | colistimethate sodium | colistin sodium methanesulfonate | colistimethate, disodium salt
Chemical Information
Molecular Formula C58H105N16Na5O28S5
CAS Registry Number 12705-41-8
SMILES CCC(C)CCCCC(=O)NC(CCNCS(=O)(=O)[O-])C(=O)NC(C(C)O)C(=O)NC(CCNCS(=O)(=O)[O-])C(=O )NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCNCS(=O)(=O)[O-])CC (C)C)CC(C)C)CCNCS(=O)(=O)[O-])CCNCS(=O)(=O)[O-])C(C)O.[Na+].[Na+].[Na+].[Na+].[N a+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Anxiety19.06.02.002--
Apnoea22.02.01.001--
Arthralgia15.01.02.001--
Asthenia08.01.01.001---
Asthma10.01.03.010; 22.03.01.002---
Blood creatinine decreased13.13.01.003---
Blood creatinine increased13.13.01.004--
Blood urea increased13.13.01.006---
Body temperature increased13.15.01.001---
Bronchospasm10.01.03.012; 22.03.01.004--
Chest discomfort02.02.02.009; 08.01.08.019; 22.12.02.002---
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Cough22.02.03.001--
Creatinine renal clearance decreased13.13.01.013---
Dermatitis23.03.04.002---
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Drug hypersensitivity10.01.01.001---
Dysarthria17.02.08.001; 19.19.03.001--
Dysgeusia07.14.03.001; 17.02.07.003--
Dysphonia17.02.08.004; 19.19.03.002; 22.12.03.006--
Dyspnoea02.11.05.003; 22.02.01.004--
Ear disorder04.03.01.001---
Epistaxis22.04.03.001; 24.07.01.005--
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Forced expiratory volume decreased13.19.01.003--
Gastrointestinal disorder07.11.01.001---
Haemoptysis02.11.04.009; 22.02.03.004; 24.07.01.006---
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