Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clotrimazole
Drug ID BADD_D00509
Description This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic activity [A174094]. It is available in various preparations, including creams, pessaries, and troche formulations (slowly dissolving tablets). As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094]. The minimal side effect profile of this drug and its uncomplicated metabolic profile have led it to gain widespread acceptance for the treatment of mycotic outbreaks such as vaginal yeast infections as well as athlete's foot [A174097].
Indications and Usage For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.
Marketing Status Prescription; OTC; Discontinued
ATC Code A01AB18; D01AC01; G01AF02
DrugBank ID DB00257
KEGG ID D00282
MeSH ID D003022
PubChem ID 2812
TTD Drug ID D09GOS
NDC Product Code 36800-508; 55301-857; 41163-963; 62512-0066; 24385-110; 11822-3078; 55315-008; 52261-5801; 71205-434; 50090-2570; 68927-3490; 68784-301; 11822-1110; 0295-6307; 63187-501; 68071-4800; 70000-0542; 73538-001; 50382-025; 62512-0064; 70673-747; 0363-2062; 69842-866; 0536-1181; 50090-0614; 24909-104; 68016-859; 79503-105; 52410-3024; 0363-1857; 49706-0545; 79481-0014; 21130-287; 69396-001; 0363-3492; 10135-671; 54633-314; 0113-0857; 11673-062; 49035-253; 51672-1260; 68071-2614; 49706-1545; 21130-210; 59779-305; 11822-0350; 54473-096; 50090-0524; 68788-7682; 24909-207; 36800-495; 68788-7402; 47832-071; 24909-106; 70795-8020; 71205-438; 0472-0220; 49035-812; 68981-045; 51552-0138; 69070-303; 76003-0329; 0904-7822; 62991-1035; 61360-2037; 30142-510; 69848-001; 59779-514; 0054-8146; 80684-039; 62512-0044; 54633-018; 68462-181; 36800-857; 51672-2037; 11523-1125; 70000-0493; 68071-2469; 50066-111; 0295-1363; 50090-0562; 55621-003; 59088-476; 63187-559; 68071-4225; 69842-062; 41520-305; 63868-690; 11822-0351; 59088-441; 45802-434; 0168-0133; 55614-650; 0395-8224; 49452-2148; 11822-0220; 0054-4146; 48087-0088; 11527-071; 70518-3396; 13746-104; 17337-0512; 11523-6549; 67510-0657; 49964-0014; 24909-208; 67234-009; 50090-4971; 63868-259; 62512-0060; 67234-014; 68788-8091; 71205-432; 0472-0350; 0536-1272; 70518-2932; 49348-793; 52389-647; 21130-870; 49035-837; 51824-063; 0363-0220; 73921-014; 50090-1770; 24909-203; 51672-1275; 37808-305; 11673-910; 72127-0801; 71399-0500; 61269-220; 52389-733; 68071-3395; 24385-205; 68071-2317; 67091-196; 43285-0043; 52389-600; 30142-305; 24909-212; 50090-5931; 49348-279; 50804-143; 48087-0086; 0536-1265; 0574-0107; 11523-0963; 38779-0019; 0363-2107; 41415-056; 51672-2062; 24909-102; 70518-0207; 65923-052; 48087-0084; 24885-777; 0363-2105; 51672-2002; 13630-0092; 66977-023; 53002-8400; 68788-9665; 49348-379; 68071-2315; 53943-990; 11673-504; 11673-857; 68016-414; 59779-712; 50090-1522; 67510-0638; 51672-2003; 66267-980; 79572-010; 0363-2109; 68071-4026; 53002-9080; 20276-105; 71399-0501; 41250-745; 68016-035
Synonyms Clotrimazole | Klotrimazole | Mycelex | FB b 5097 | Lotrimin | Bay b 5097 | Canesten | Kanesten
Chemical Information
Molecular Formula C22H17ClN2
CAS Registry Number 23593-75-1
SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abortion spontaneous18.01.04.0010.001034%Not Available
Ageusia07.14.03.003; 17.02.07.001--Not Available
Angioedema10.01.05.009; 23.04.01.0010.001034%Not Available
Aspartate aminotransferase increased13.03.01.006--
Bladder pain20.02.02.001--Not Available
Blister12.01.06.002; 23.03.01.001--Not Available
Burning sensation08.01.09.029; 17.02.06.001--Not Available
Cellulitis11.02.01.001; 23.09.01.0010.000689%Not Available
Cystitis11.01.14.001; 20.03.02.002--
Dermatitis23.03.04.0020.000689%Not Available
Dermatitis bullous23.03.01.002--
Drug dependence19.07.02.0090.000689%Not Available
Dyspnoea02.01.03.002; 22.02.01.0040.000689%
Erythema23.03.06.0010.001034%Not Available
Flatulence07.01.04.002--
Haemoglobin13.01.05.018--Not Available
Hyperhidrosis08.01.03.028; 23.02.03.0040.000689%
Hypersensitivity10.01.03.0030.004482%
Lip swelling07.05.04.005; 10.01.05.005; 23.04.01.0070.000689%Not Available
Liver function test abnormal13.03.01.013--Not Available
Migraine17.14.02.001; 24.03.05.0030.000689%Not Available
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Oedema08.01.07.006; 14.05.06.010--Not Available
Pain08.01.08.004--
Panic attack19.06.04.0010.000689%Not Available
Pollakiuria20.02.02.007--
Pruritus23.03.12.0010.001379%
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ADReCS-Target
Drug Name ADR Term Target
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