Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clorazepic acid
Drug ID BADD_D00507
Description A water-soluble benzodiazepine derivative effective in the treatment of anxiety. It has also muscle relaxant and anticonvulsant actions.
Indications and Usage For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Also used as adjunctive therapy in the management of partial seizures and for the symptomatic relief of acute alcohol withdrawal.
Marketing Status Prescription; Discontinued
ATC Code N05BA05
DrugBank ID DB00628
KEGG ID D00694
MeSH ID D003009
PubChem ID 2809
TTD Drug ID D0P3JU
NDC Product Code Not Available
Synonyms Clorazepate Dipotassium | Dipotassium Chlorazepate | 4306-CB | Chlorazepate | Clorazepate | Tranxene | Tranxilium | Clorazepic Acid | Clorazepate Monopotassium
Chemical Information
Molecular Formula C16H11ClN2O3
CAS Registry Number 23887-31-2
SMILES C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaemia01.03.02.0010.007077%
Asthenia08.01.01.001--Not Available
Ataxia08.01.02.004; 17.02.02.001--
Blood pressure systolic decreased13.14.03.007--Not Available
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.001231%Not Available
Cholelithiasis09.03.01.0020.004718%Not Available
Colitis ischaemic07.08.01.004; 24.04.08.0120.007077%Not Available
Coma17.02.09.0010.016514%Not Available
Confusional state17.02.03.005; 19.13.01.0010.004718%
Dehydration14.05.05.0010.004718%
Dermatitis23.03.04.002--Not Available
Diplopia06.02.06.002; 17.17.01.005--Not Available
Disturbance in attention17.03.03.001; 19.21.02.0020.007077%
Dizziness02.01.02.004; 17.02.05.003; 24.06.02.0070.007077%
Drug abuse19.07.02.0100.011795%Not Available
Drug dependence19.07.02.0090.004718%Not Available
Dry mouth07.06.01.002--
Dysarthria17.02.08.001; 19.19.03.001--
Dystonia17.01.03.0010.004718%Not Available
Electrocardiogram QT prolonged13.14.05.0040.001231%
Eosinophilia01.02.04.0010.004718%
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Haematocrit decreased13.01.05.001--Not Available
Headache17.14.01.0010.007077%
Hyperkalaemia14.05.03.0010.007077%
Hyperthermia08.05.01.001; 12.05.01.0020.004718%Not Available
Hypotension24.06.03.0020.007077%
Hypothermia08.05.01.003; 12.05.03.0010.004718%
Insomnia17.15.03.002; 19.02.01.002--
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