Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Citric acid
Drug ID BADD_D00477
Description A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability. Citric acid was one of active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020.[L14120]
Indications and Usage Not Available
Marketing Status approved; nutraceutical; vet_approved
ATC Code A09AB04
DrugBank ID DB04272
KEGG ID D01222
MeSH ID D019343
PubChem ID 311
TTD Drug ID D02RTS
NDC Product Code 81803-040
UNII XF417D3PSL
Synonyms Citric Acid | Citric Acid Monohydrate | Uralyt U | Citrate | Citric Acid, Anhydrous | Anhydrous Citric Acid
Chemical Information
Molecular Formula C6H8O7
CAS Registry Number 77-92-9
SMILES C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal pain07.01.05.0020.199009%
Abdominal pain upper07.01.05.003--
Apathy19.04.04.002---
Asthenia08.01.01.0010.905673%-
Blood calcium decreased13.11.01.002---
Chills08.01.09.001; 15.05.03.0160.474384%
Cold sweat08.01.03.024; 23.02.03.0020.001816%-
Confusional state17.02.03.005; 19.13.01.0010.178162%
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.0071.861170%
Dysarthria17.02.08.001; 19.19.03.001--
Dysgeusia07.14.03.001; 17.02.07.0030.708481%
Dyspepsia07.01.02.0010.494735%
Electrocardiogram abnormal13.14.05.001---
Electrocardiogram QRS complex13.14.05.034---
Electrocardiogram ST segment13.14.05.035---
Feeling abnormal08.01.09.014---
Feeling hot08.01.09.0091.836733%-
Flat affect19.04.01.004---
Headache17.14.01.0010.148771%
Hyperhidrosis08.01.03.028; 23.02.03.0041.440532%
Hyperkalaemia14.05.03.001--
Hypoaesthesia17.02.06.023; 23.03.03.0810.037647%-
Hypocalcaemia14.04.01.004--
Hypotension24.06.03.002--
Injection site haematoma08.02.03.004; 12.07.03.004; 24.07.01.0090.168420%-
Liver disorder09.01.08.001---
Movement disorder17.01.02.0100.010733%-
Muscle spasms15.05.03.0040.050361%
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