Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cidofovir dihydrate
Drug ID BADD_D00464
Description Cidofovir is an injectable antiviral medication employed in the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS. It suppresses CMV replication through selective inhibition of viral DNA synthesis.[FDA label] It was manufactured by _Gilead_ and initially approved by the FDA in 1996, but has since been discontinued.[L6223]
Indications and Usage For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)
Marketing Status approved
ATC Code J05AB12
DrugBank ID DB00369
KEGG ID D00273
MeSH ID D000077404
PubChem ID 60933
TTD Drug ID D04AAW
NDC Product Code 14593-840; 71052-483; 73309-228; 82891-006; 82772-002; 23155-216; 73377-064
UNII JIL713Q00N
Synonyms Cidofovir | HPMPC | GS 504 | GS-504 | GS504 | Cidofovir, Sodium Salt | Cidofovir Sodium | Cidofovir, (R)-isomer | Cidofovir Anhydrous | 1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine | 1-((3-Hydroxy-2-phosphonylmethoxy)propyl)cytosine | Vistide | Cidofovir, (+-)-isomer
Chemical Information
Molecular Formula C8H18N3O8P
CAS Registry Number 149394-66-1
SMILES C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O.O.O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pneumonia11.01.09.003; 22.07.01.003---
Pneumothorax22.05.02.003--
Polyuria20.02.03.002---
Proctitis07.08.04.001--
Prostatic disorder21.04.01.001---
Proteinuria20.02.01.011--
Pruritus23.03.12.001--
Pseudolymphoma01.09.01.016---
Pyrexia08.05.02.003--
Rash23.03.13.001---
Refraction disorder06.02.04.004---
Respiratory alkalosis14.01.05.001; 22.02.02.005---
Retinal detachment06.09.03.003; 12.01.04.004--
Retinal disorder06.08.03.005---
Rhinitis11.01.13.004; 22.07.03.006--
Sarcoma15.09.03.002; 16.33.01.002---
Seborrhoea23.02.07.001---
Seizure17.12.03.001--
Sepsis11.01.11.003--
Shock24.06.02.002---
Sinusitis11.01.13.005; 22.07.03.007--
Skin discolouration23.03.03.005---
Skin disorder23.03.03.007---
Skin hypertrophy23.01.04.002---
Skin ulcer23.07.03.003; 24.04.03.007--
Somnolence17.02.04.006; 19.02.05.003--
Speech disorder17.02.08.003; 19.19.02.002; 22.12.03.027---
Spleen disorder01.09.02.003---
Splenomegaly01.09.02.001---
Sputum increased22.02.03.007---
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