Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Cholestyramine
Drug ID BADD_D00451
Description Cholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins. Cholestyramine resin is quite hydrophilic, but insoluble in water.
Indications and Usage Indicated as adjunctive therapy to diet for the reduction of elevated serum cholesterol in patients with primary hypercholesterolemia (elevated low density lipoprotein [LDL] cholesterol) who do not respond adequately to diet. Also for the relief of pruritus associated with partial biliary obstruction.
Marketing Status approved; investigational
ATC Code C10AC01
DrugBank ID DB01432
KEGG ID D02690
MeSH ID D002792
PubChem ID 137699107
TTD Drug ID Not Available
NDC Product Code 68444-0001; 49884-936; 51224-009; 63629-2163; 42806-266; 42806-267; 0245-0036; 68382-528; 24658-266; 27241-134; 68382-529; 70771-1105; 0832-0536; 49884-465; 0245-0536; 62559-620; 63629-2164; 70771-1070; 53933-2175; 71052-151; 0185-0940; 49884-937; 63629-2162; 42806-265; 51927-4962; 51224-011; 49884-466; 63629-2161
UNII 4B33BGI082
Synonyms Cholestyramine Resin | Cholestyramine Resins | Resin, Cholestyramine | Resins, Cholestyramine | Colestyramin | Colestyramins | Colestyramine | Colestyramines | Cholestyramine | Cholestyramines | MK-135 | MK 135 | MK135 | Questran | Questrans | Cuemid | Cuemids | Quantalan | Quantalans
Chemical Information
Molecular Formula C27H47ClN2
CAS Registry Number 11041-12-6
SMILES CCC(C)C.CCC(CC(C)C1=CC=CC=C1)C2=CC=C(C=C2)C[N+](C)(C)C.N.[Cl-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal pain07.01.05.002--
Acidosis hyperchloraemic14.01.01.007---
Anaemia01.03.02.001--
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Asthma10.01.03.010; 22.03.01.002---
Back pain15.03.04.005--
Biliary colic09.02.01.001---
Calcification metastatic08.03.04.006; 14.04.01.011---
Constipation07.02.02.001--
Death08.04.01.001--
Dental caries07.09.01.001--
Diarrhoea07.02.01.001--
Diverticulitis07.10.02.001; 11.01.07.003---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Duodenal ulcer haemorrhage07.04.02.004; 24.07.02.020---
Dysgeusia07.14.03.001; 17.02.07.003--
Dysphagia07.01.06.003--
Dyspnoea02.11.05.003; 22.02.01.004--
Dysuria20.02.02.002--
Ecchymosis01.01.03.001; 23.06.01.001; 24.07.06.002---
Eructation07.01.02.003--
Erythema23.03.06.001---
Faeces discoloured07.01.03.002---
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Gingival bleeding07.09.07.001; 24.07.02.010---
Glossitis07.14.01.001---
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