Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Chlorpromazine
Drug ID BADD_D00445
Description The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
Indications and Usage For the treatment of schizophrenia; to control nausea and vomiting; for relief of restlessness and apprehension before surgery; for acute intermittent porphyria; as an adjunct in the treatment of tetanus; to control the manifestations of the manic type of manic-depressive illness; for relief of intractable hiccups; for the treatment of severe behavioral problems in children (1 to 12 years of age) marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations), and in the short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability, and poor frustration tolerance.
Marketing Status approved; investigational; vet_approved
ATC Code N05AA01
DrugBank ID DB00477
KEGG ID D00270
MeSH ID D002746
PubChem ID 2726
TTD Drug ID D01ZII
NDC Product Code 62332-735; 70518-3175; 63304-083; 63304-114; 62332-738; 62332-737; 63304-122; 62332-739; 63304-143; 62332-736; 63304-185
UNII U42B7VYA4P
Synonyms Chlorpromazine | Thorazine | Aminazine | Largactil | Chlordelazine | Chlorpromazine Hydrochloride | Hydrochloride, Chlorpromazine | Contomin | Fenactil | Propaphenin | Chlorazine
Chemical Information
Molecular Formula C17H19ClN2S
CAS Registry Number 34468-21-8
SMILES CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tremor17.01.06.002--
Trismus15.05.04.004; 17.01.03.004--
Unresponsive to stimuli17.02.05.0310.000677%-
Urinary incontinence17.05.01.008; 20.02.02.0100.000677%
Urinary retention20.02.02.011--
Vertigo04.04.01.003; 17.02.12.002--
Vision blurred06.02.06.007; 17.17.01.010--
Visual impairment06.02.10.013---
Mental status changes19.07.01.0010.000677%-
Brain oedema12.01.10.010; 17.07.02.003--
Conjunctival hyperaemia06.04.01.0040.000677%-
Acquired haemophilia01.01.01.0020.001355%-
Faecaloma07.01.03.004---
Parkinsonian rest tremor17.01.05.009---
Erectile dysfunction19.08.04.001; 21.03.01.007--
Blood disorder01.05.01.004---
Disease recurrence08.01.03.0500.000677%-
Pigmentation disorder23.05.03.001---
Hypophagia07.01.06.010; 14.03.01.006; 19.09.01.0040.000677%-
Oropharyngeal discomfort07.05.05.008; 22.12.03.015---
Oropharyngeal pain07.05.05.004; 22.12.03.016--
Drug-induced liver injury09.01.07.023; 12.03.01.0440.000677%-
Drug reaction with eosinophilia and systemic symptoms10.01.01.021; 12.03.01.064; 23.03.05.0050.000677%-
Dermatitis exfoliative generalised10.01.01.029; 23.03.07.002---
Sopor17.02.04.021; 19.02.04.0020.000677%-
Heavy menstrual bleeding21.01.03.005---
Hepatic cytolysis09.01.07.0360.000677%-
Reduced facial expression17.01.05.016; 19.01.02.021---
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ADReCS-Target
Drug Name ADR Term Target
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