Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Chlorothiazide sodium
Drug ID BADD_D00443
Description A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
Indications and Usage Chlorothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.
Marketing Status approved; vet_approved
ATC Code C03AA04
DrugBank ID DB00880
KEGG ID D03471
MeSH ID D002740
PubChem ID 23675744
TTD Drug ID D0M9WM
NDC Product Code 47335-330; 25021-305; 0517-1820; 63323-658; 76478-711; 17478-419
UNII SN86FG7N2K
Synonyms Chlorothiazide
Chemical Information
Molecular Formula C7H5ClN3NaO4S2
CAS Registry Number 7085-44-1
SMILES C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)[N-]C=N2.[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agranulocytosis01.02.03.001---
Alopecia23.02.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Aplastic anaemia01.03.03.002---
Asthenia08.01.01.001---
Constipation07.02.02.001--
Cutaneous vasculitis10.02.02.003; 23.06.02.001; 24.12.04.008---
Dermatitis exfoliative10.01.01.004; 23.03.07.001--
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Electrolyte imbalance14.05.01.002---
Erythema multiforme10.01.03.015; 23.03.01.003--
Glycosuria20.02.01.005--
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Haemolytic anaemia01.06.03.002---
Headache17.14.01.001--
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hyperuricaemia14.09.01.003--
Hypotension24.06.03.002--
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.030---
Jaundice cholestatic09.01.01.005---
Leukopenia01.02.02.001---
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Orthostatic hypotension17.05.01.020; 24.06.03.004---
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005; 23.03.03.094--
Photosensitivity reaction23.03.09.003--
Purpura01.01.04.003; 23.06.01.004; 24.07.06.005--
Pyrexia08.05.02.003--
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