Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Chloramphenicol sodium succinate
Drug ID BADD_D00431
Description Chloramphenicol succinate is an ester prodrug of [chloramphenicol].[A192987] Chloramphenicol is a bacteriostatic antibiotic.[A204065] Use of chloramphenicol succinate and chloramphenicol has decreased due to the risk of potentially fatal blood dyscrasias.[L14174] Chloramphenicol succinate was granted FDA approval on 20 February 1959.[L12711]
Indications and Usage Chloramphenicol succinate is indicated to treat serious and susceptible bacterial infections where less dangerous drugs are ineffective or contraindicated.[L12711]
Marketing Status approved
ATC Code Not Available
DrugBank ID DB07565
KEGG ID D02185
MeSH ID C026016
PubChem ID 656833
TTD Drug ID Not Available
NDC Product Code 63323-011
UNII 872109HX6B
Synonyms chloramphenicol succinate | levomycetin succinate | chloramphenicol hemisuccinate | chloramphenicol monosuccinate | chloramphenicol succinate sodium | chloramphenicol sodium succinate
Chemical Information
Molecular Formula C15H15Cl2N2NaO8
CAS Registry Number 982-57-0
SMILES C1=CC(=CC=C1C(C(COC(=O)CCC(=O)[O-])NC(=O)C(Cl)Cl)O)[N+](=O)[O-].[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Aplastic anaemia01.03.03.002---
Diarrhoea07.02.01.001--
Enterocolitis07.08.03.003--
Glossitis07.14.01.001---
Granulocytopenia01.02.03.003---
Hypoplastic anaemia01.03.03.006---
Jarisch-Herxheimer reaction10.02.01.002---
Leukopenia01.02.02.001---
Nausea07.01.07.001--
Pancytopenia01.03.03.003---
Pyrexia08.05.02.003--
Rash macular23.03.13.003---
Rash vesicular23.03.13.009---
Reticulocyte count decreased13.01.05.009---
Stomatitis07.05.06.005--
Thrombocytopenia01.08.01.002---
Urticaria10.01.06.001; 23.04.02.001--
Vomiting07.01.07.003--
Bone marrow failure01.03.03.005--
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