Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Cevimeline
Drug ID BADD_D00424
Description Cevimeline is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögren's syndrome.
Indications and Usage For the treatment of symptoms of dry mouth in patients with Sjögren's Syndrome.
Marketing Status approved
ATC Code N07AX03
DrugBank ID DB00185
KEGG ID D07667
MeSH ID C059240
PubChem ID 2684
TTD Drug ID D0Q4CS
NDC Product Code 64642-011; 63304-479
UNII K9V0CDQ56E
Synonyms cevimeline | 2-methyspiro(1,3-oxathiolane-5,3)quinuclidine | AF 102B, (trans)-isomer | AF-102B | AF 102B | AF102B | Evoxac | FKS 508 | FKS-508 | SNI 2011 | SNI-2011 | AF 102B, (cis-(+))-isomer | cevimeline hydrochloride
Chemical Information
Molecular Formula C10H17NOS
CAS Registry Number 124620-88-8
SMILES CC1OC2(CN3CCC2CC3)CS1
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Atrophic vulvovaginitis21.02.01.003---
Back pain15.03.04.005--
Basal cell carcinoma16.03.02.001; 23.08.02.001---
Basosquamous carcinoma16.16.01.012---
Bladder discomfort20.02.02.019---
Bladder pain20.02.02.001---
Blepharitis06.04.04.001; 23.03.04.012---
Blood creatine phosphokinase increased13.04.01.001--
Blood lactate dehydrogenase increased13.04.02.002--
Blood pressure fluctuation24.06.01.002---
Blood triglycerides increased13.12.03.001---
Blood urea increased13.13.01.006---
Blood uric acid increased13.02.04.001---
Body temperature increased13.15.01.001---
Bone disorder15.02.04.004---
Bone pain15.02.01.001--
Breast cancer16.10.01.001; 21.05.01.003---
Breast neoplasm16.10.02.001; 21.05.01.004---
Breast pain21.05.05.003--
Bronchitis11.01.09.001; 22.07.01.001--
Bronchospasm10.01.03.012; 22.03.01.004--
Bundle branch block02.03.01.009---
Bursitis12.04.03.010; 15.04.01.001---
Cardiac murmur13.14.01.001---
Cardiomegaly02.04.02.001---
Cardiovascular disorder02.11.01.010; 24.03.02.009---
Carpal tunnel syndrome17.09.02.001---
Cataract06.06.01.001--
Cellulitis11.02.01.001; 23.11.02.004---
Change of bowel habit07.02.03.002---
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