Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Cefuroxime
Drug ID BADD_D00407
Description Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
Indications and Usage For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.
Marketing Status approved
ATC Code J01DC02; S01AA27
DrugBank ID DB01112
KEGG ID D00262
MeSH ID D002444
PubChem ID 41375
TTD Drug ID D0Y2IE
NDC Product Code 0143-9567; 0143-9569; 0143-9976; 0143-9568; 0143-9977; 0143-9979
UNII O1R9FJ93ED
Synonyms Cefuroxime | Cephuroxime | Zinacef | Ketocef
Chemical Information
Molecular Formula C16H16N4O8S
CAS Registry Number 55268-75-2
SMILES CON=C(C1=CC=CO1)C(=O)NC2C3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatic function abnormal09.01.02.001---
Hepatitis09.01.07.0040.000143%-
Hepatitis toxic09.01.07.017; 12.03.01.0160.000143%-
Hepatocellular injury09.01.07.0080.000143%-
Hepatosplenomegaly01.09.03.001; 09.01.05.0020.000215%-
Hyperaesthesia17.02.06.004; 23.03.03.0800.000143%-
Hyperhidrosis08.01.03.028; 23.02.03.0040.001245%
Hyperkinesia17.01.02.008---
Hypersensitivity10.01.03.0030.004478%
Hypersensitivity vasculitis01.01.04.008; 10.02.02.017; 23.06.02.005; 24.12.04.0130.000215%-
Hypoaesthesia17.02.06.023; 23.03.03.081---
Hypoalbuminaemia09.01.02.003; 14.10.01.0020.000286%
Hypocalcaemia14.04.01.0040.000215%
Hypokalaemia14.05.03.0020.000286%
Hypotension24.06.03.0020.002504%
Hypothermia08.05.01.003; 12.05.03.0010.000143%
Hypotonia neonatal15.05.04.012; 17.05.02.010; 18.04.01.0060.000143%-
Immune system disorder10.02.01.001---
Influenza like illness08.01.03.010--
Injection site pain08.02.03.010; 12.07.03.011---
Irritability08.01.03.011; 19.04.02.013--
Jarisch-Herxheimer reaction10.02.01.002---
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.0300.000286%-
Joint swelling15.01.02.004---
Laryngeal oedema10.01.05.003; 22.04.02.001; 23.04.01.0050.000143%
Leukocytosis01.02.01.0020.000358%
Leukopenia01.02.02.001---
Linear IgA disease10.04.02.006; 23.03.01.0150.000816%-
Lip oedema07.05.04.004; 10.01.05.004; 23.04.01.0060.000286%-
Lip swelling07.05.04.005; 10.01.05.005; 23.04.01.0070.000887%-
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ADReCS-Target
Drug Name ADR Term Target
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