ADReCS

Pharmaceutical Information

Drug Name	Cefuroxime
Drug ID	BADD_D00407
Description	Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
Indications and Usage	For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.
Marketing Status	approved
ATC Code	J01DC02; S01AA27
DrugBank ID	DB01112
KEGG ID	D00262
MeSH ID	D002444
PubChem ID	41375
TTD Drug ID	D0Y2IE
NDC Product Code	0143-9567; 0143-9569; 0143-9976; 0143-9568; 0143-9977; 0143-9979
UNII	O1R9FJ93ED
Synonyms	Cefuroxime \| Cephuroxime \| Zinacef \| Ketocef

Chemical Information

Molecular Formula	C16H16N4O8S
CAS Registry Number	55268-75-2
SMILES	CON=C(C1=CC=CO1)C(=O)NC2C3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Erythema multiforme	10.01.03.015; 23.03.01.003	-	-
Extravasation	08.01.03.008	0.000315%		-
Eye inflammation	06.04.05.002	0.000715%		-
Eye irritation	06.04.05.003	0.000315%		-
Eye swelling	06.08.03.003	0.000701%		-
Eyelid oedema	06.04.04.004; 10.01.05.001; 23.04.01.003	0.000529%		-
Face oedema	08.01.07.003; 10.01.05.002; 23.04.01.004	0.000930%
Feeling cold	08.01.09.008	0.000143%		-
Feeling hot	08.01.09.009	0.000458%		-
Flatulence	07.01.04.002	0.000529%
Flushing	08.01.03.025; 23.06.05.003; 24.03.01.002	0.001102%
Foetal distress syndrome	18.03.02.003	0.000358%		-
Frequent bowel movements	07.02.04.002	0.000458%		-
Gastritis	07.08.02.001	0.000143%
Gastrointestinal disorder	07.11.01.001	-	-	-
Gastrointestinal infection	07.19.02.005; 11.01.07.012	-	-	-
Gastrointestinal pain	07.01.05.005	0.000486%
Generalised oedema	08.01.07.004; 14.05.06.007	0.000429%
Generalised tonic-clonic seizure	17.12.01.002	0.000143%		-
Glaucoma	06.03.01.002	0.000143%
Groin pain	15.03.02.004	-	-	-
Haematocrit decreased	13.01.05.001	-	-	-
Haemoglobin	13.01.05.018	-	-	-
Haemoglobin decreased	13.01.05.003	-	-	-
Haemolysis	01.06.04.002	0.000143%
Haemolytic anaemia	01.06.03.002	0.000143%		-
Haemoptysis	02.11.04.009; 22.02.03.004; 24.07.01.006	0.000143%		-
Head discomfort	17.02.05.027	0.000143%		-
Headache	17.14.01.001	-	-
Hepatic failure	09.01.03.002	0.000215%

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