Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Cefuroxime
Drug ID BADD_D00407
Description Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
Indications and Usage For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.
Marketing Status approved
ATC Code J01DC02; S01AA27
DrugBank ID DB01112
KEGG ID D00262
MeSH ID D002444
PubChem ID 41375
TTD Drug ID D0Y2IE
NDC Product Code 0143-9567; 0143-9569; 0143-9976; 0143-9568; 0143-9977; 0143-9979
UNII O1R9FJ93ED
Synonyms Cefuroxime | Cephuroxime | Zinacef | Ketocef
Chemical Information
Molecular Formula C16H16N4O8S
CAS Registry Number 55268-75-2
SMILES CON=C(C1=CC=CO1)C(=O)NC2C3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Renal impairment20.01.03.010---
Complex regional pain syndrome12.01.12.004; 17.02.07.0100.000215%-
Vulvovaginal mycotic infection11.03.05.004; 21.14.02.004---
Cardiovascular insufficiency02.11.01.011; 24.06.03.0050.000143%-
Treatment failure08.06.01.0170.000358%-
Liver injury09.01.07.022; 12.01.17.0120.000286%-
Adverse reaction08.06.01.0180.000143%-
Low birth weight baby18.04.02.0030.000143%-
Brain injury17.11.01.003; 19.07.03.0070.000215%-
Cholestatic liver injury09.01.07.0160.000143%-
Oropharyngeal discomfort07.05.05.008; 22.12.03.0150.000143%-
Kounis syndrome02.02.02.020; 10.01.03.037; 24.04.04.0200.002504%-
Macular fibrosis06.09.03.0140.000286%-
Drug-induced liver injury09.01.07.023; 12.03.01.0440.001145%-
Drug reaction with eosinophilia and systemic symptoms10.01.01.021; 12.03.01.064; 23.03.05.0050.001145%-
Candida infection11.03.03.021--
Mouth swelling07.05.04.007; 10.01.05.020; 23.04.01.020---
Multiple organ dysfunction syndrome08.01.03.0570.000501%
Anal incontinence07.01.06.029; 17.05.01.0210.000215%
Alcohol interaction08.06.03.0030.000358%-
Arthritis reactive06.04.05.031; 10.02.01.070; 11.07.01.013; 15.01.09.004; 20.08.02.0140.000215%-
Normal newborn18.08.06.0010.000558%-
Retinal cyst06.09.03.0220.000143%-
Small for dates baby18.04.02.0020.000143%-
Vitritis06.04.06.0130.000215%-
Retinal infarction06.10.01.012; 24.04.10.0080.002504%-
Retinal neovascularisation05.07.01.006; 06.10.01.013; 14.07.01.006; 24.03.07.0150.000215%-
Bradycardia neonatal02.03.02.019; 18.04.07.0040.000143%-
Palatal oedema07.05.04.0080.000143%-
Retinoschisis06.09.03.0250.000429%-
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ADReCS-Target
Drug Name ADR Term Target
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