Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ceftobiprole
Drug ID BADD_D00404
Description Ceftobiprole is a cephalosporin antibiotic with activity against methicillin-resistant Staphylococcus aureus. It was discovered by Basilea Pharmaceutica and is being developed by Johnson & Johnson Pharmaceutical Research and Development. Ceftobiprole is the first cephalosporin to demonstrate clinical efficacy in patients with infections due to methicillin-resistant staphylococci and, if approved by regulatory authorities, is expected to be a useful addition to the armamentarium of agents for the treatment of complicated skin infections and pneumonia.
Indications and Usage For the treatment of serious bacterial infections in hospitalised patients.
Marketing Status approved; investigational
ATC Code Not Available
DrugBank ID DB04918
KEGG ID D08885
MeSH ID C443755
PubChem ID 135413542
TTD Drug ID D0CI9T
NDC Product Code Not Available
UNII 5T97333YZK
Synonyms ceftobiprole | BAL9141 | BAL 9141
Chemical Information
Molecular Formula C20H22N8O6S2
CAS Registry Number 209467-52-7
SMILES C1CNCC1N2CCC(=CC3=C(N4C(C(C4=O)NC(=O)C(=NO)C5=NSC(=N5)N)SC3)C(=O)O)C2=O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Fungal infection11.03.05.001---
Gamma-glutamyltransferase increased13.03.04.024--
Gastrointestinal disorder07.11.01.001---
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hyponatraemia14.05.04.002--
Immune system disorder10.02.01.001---
Insomnia17.15.03.002; 19.02.01.002--
Liver function test abnormal13.03.04.030---
Menopausal symptoms21.02.02.002---
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001---
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Osteomyelitis11.01.01.001; 15.02.05.001--
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Phlebitis12.02.01.002; 24.12.03.004--
Pollakiuria20.02.02.007--
Pruritus23.03.12.001--
Rash23.03.13.001---
Rash maculo-papular23.03.13.004--
Seizure17.12.03.001--
Skin disorder23.03.03.007---
Somnolence17.02.04.006; 19.02.05.003--
Thrombocytosis01.08.02.001---
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