Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ceftizoxime
Drug ID BADD_D00402
Description A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
Indications and Usage Cetizoxime was previously indicated for the treatment of infections due to susceptible strains of bacteria.
Marketing Status approved; withdrawn
ATC Code J01DD07
DrugBank ID DB01332
KEGG ID D07658
MeSH ID D015296
PubChem ID 2655
TTD Drug ID D0Y7BD
NDC Product Code Not Available
UNII C43C467DPE
Synonyms Ceftizoxime | Ceftizoxime Sodium | Sodium, Ceftizoxime | Ceftizoxime Monosodium Salt | Monosodium Salt, Ceftizoxime | Salt, Ceftizoxime Monosodium | SKF-88373 | SKF 88373 | SKF88373 | FR-13749 | FR 13749 | FR13749 | SK&F 88373-2 | SK&F 88373 2 | SK&F 883732 | Cefizox | FK749 | FK-749 | FK 749
Chemical Information
Molecular Formula C13H13N5O5S2
CAS Registry Number 68401-81-0
SMILES CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=CCS3)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agranulocytosis01.02.03.001---
Alanine aminotransferase increased13.03.04.005--
Anaemia01.03.02.001--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactic shock10.01.07.002; 24.06.02.004---
Aplastic anaemia01.03.03.002---
Aspartate aminotransferase increased13.03.04.011--
Blood bilirubin increased13.03.04.018--
Blood creatinine increased13.13.01.004--
Blood lactate dehydrogenase increased13.04.02.002--
Blood urea increased13.13.01.006---
Body temperature increased13.15.01.001---
Cellulitis11.02.01.001; 23.11.02.004---
Death08.04.01.001--
Dermatitis23.03.04.002---
Diarrhoea07.02.01.001--
Eosinophilia01.02.04.001--
Erythema multiforme10.01.03.015; 23.03.01.003--
Haemoglobin13.01.05.018---
Haemolytic anaemia01.06.03.002---
Hypersensitivity10.01.03.003--
Hypoaesthesia17.02.06.023; 23.03.03.081---
Injection site pain08.02.03.010; 12.07.03.011---
Leukopenia01.02.02.001---
Nausea07.01.07.001--
Nephropathy toxic12.03.01.010; 20.05.03.002---
Neutropenia01.02.03.004---
Pain08.01.08.004--
Pancytopenia01.03.03.003---
Paraesthesia17.02.06.005; 23.03.03.094--
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