Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Ceftaroline fosamil
Drug ID BADD_D00398
Description Ceftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and skin structure infections. Community-acquired bacterial pneumonia.
Indications and Usage Ceftaroline fosamil is indicated for the treatment of patients with the following infections caused by susceptible isolates of the designated microorganisms.
Marketing Status approved; investigational
ATC Code J01DI02
DrugBank ID DB06590
KEGG ID D08884
MeSH ID C515501
PubChem ID 9852981
TTD Drug ID Not Available
NDC Product Code 0456-0400; 0456-0600
UNII 7P6FQA5D21
Synonyms ceftaroline fosamil | Teflaro | TAK-599 | TAK599 | PPI-0903 | PPI0903
Chemical Information
Molecular Formula C22H21N8O8PS4
CAS Registry Number 229016-73-3
SMILES CCON=C(C1=NSC(=N1)NP(=O)(O)O)C(=O)NC2C3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C= C5)C)C(=O)[O-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.0010.000073%-
Anaemia01.03.02.0010.000107%
Anaphylactic reaction10.01.07.001; 24.06.03.0060.000073%
Anaphylactic shock10.01.07.002; 24.06.02.004---
Body temperature increased13.15.01.001---
Bradycardia02.03.02.002---
Clostridium difficile colitis07.19.01.004; 11.02.02.004---
Confusional state17.02.03.005; 19.13.01.0010.000049%
Constipation07.02.02.001--
Coombs direct test positive13.01.01.001---
Death08.04.01.0010.000267%
Dermatitis23.03.04.002---
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dysarthria17.02.08.001; 19.19.03.0010.000107%
Dyspnoea02.11.05.003; 22.02.01.0040.000131%
Eosinophilia01.02.04.001--
Erythema23.03.06.0010.000049%-
Extravasation08.01.03.0080.000165%-
Face oedema08.01.07.003; 10.01.05.002; 23.04.01.0040.000107%
Gastrointestinal disorder07.11.01.001---
Gastrointestinal pain07.01.05.005--
Haemolytic anaemia01.06.03.0020.000073%-
Headache17.14.01.001--
Hepatitis09.01.07.004---
Hepatotoxicity09.01.07.009; 12.03.01.0080.000049%-
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hyperkalaemia14.05.03.001--
Hypersensitivity10.01.03.003--
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