| Pharmaceutical Information |
| Drug Name |
Cefoperazone |
| Drug ID |
BADD_D00389 |
| Description |
Cefoperazone is a semisynthetic broad-spectrum cephalosporin proposed to be effective against Pseudomonas infections. It is a third-generation antiobiotic agent and it is used in the treatment of various bacterial infections caused by susceptible organisms in the body, including respiratory tract infections, peritonitis, skin infections, endometritis, and bacterial septicemia. While its clinical use has been discontinued in the U.S., cefoperazone is available in several European countries most commonly under the product name, Sulperazon. |
| Indications and Usage |
Indicated for the treatment of following infections caused by susceptible bacteria:[label]
1) Respiratory tract infections caused by _S. pneumoniae_, _H. influenzae_, _S. aureus_ (penicillinase and non-penicillinase producing strains), _S. pyogenes_ (Group A beta-hemolytic streptococci), _P. aeruginosa_, _Klebsiella pneumoniae_, _E. coli_, _Proteus mirabilis_, and Enterobacter species.
2) Peritonitis and other intra-abdominal infections caused by _E. coli_, _P. aeruginosa_, and anaerobic gram-negative bacilli (including _Bacteroides fragilis_).
3) Bacterial septicemia caused by _S. pneumoniae_, _S. agalactiae_, _S. aureus_, _Pseudomonas aeruginosa_, _E. coli_, _Klebsiella_ spp., _Klebsiella pneumoniae_, Proteus species (indole-positive and indole-negative), _Clostridium_ spp. and anaerobic gram-positive cocci.
4) Infections of the skin and skin structures caused by S. aureus (penicillinase and non-penicillinase producing strains), S. pyogenes, and P. aeruginosa.
5) Pelvic Inflammatory Disease, Endometritis, and Other Infections of the Female Genital Tract caused by N. gonorrhoeae, S. epidermidis, S. agalactiae, E. coli, Clostridium spp., Bacteroides species (including Bacteroides fragilis), and anaerobic gram-positive cocci.
6) Urinary tract infections caused by Escherichia coli and Pseudomonas aeruginosa.
7) Enterococcal Infections. Although cefoperazone has been shown to be clinically effective in the treatment of infections caused by enterococci in cases of peritonitis and other intra-abdominal infections, infections of the skin and skin structures, pelvic inflammatory disease, endometritis and other infections of the female genital tract, and urinary tract infections, the majority of clinical isolates of enterococci tested are not susceptible to cefoperazone but fall just at or in the intermediate zone of susceptibility, and are moderately resistant to cefoperazone. However, _in vitro_ susceptibility testing may not correlate directly with _in vivo_ results. Despite this, cefoperazone therapy has resulted in clinical cures of enterococcal infections, chiefly in polymicrobial infections. Cefoperazone should be used in enterococcal infections with care and at doses that achieve satisfactory serum levels of cefoperazone. |
| Marketing Status |
approved; investigational |
| ATC Code |
J01DD12 |
| DrugBank ID |
DB01329
|
| KEGG ID |
D07645
|
| MeSH ID |
D002438
|
| PubChem ID |
44187
|
| TTD Drug ID |
D0C2YB
|
| NDC Product Code |
Not Available |
| UNII |
7U75I1278D
|
| Synonyms |
Cefoperazone | Cefoperazon | Cefoperazone Sodium | Sodium, Cefoperazone | Cefoperazone Sodium Salt | Salt, Cefoperazone Sodium | Sodium Salt, Cefoperazone | T1551 | T-1551 | T 1551 | Cefobid | Céfobis |
|
| Chemical Information |
| Molecular Formula |
C25H27N9O8S2 |
| CAS Registry Number |
62893-19-0 |
| SMILES |
CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=C(C=C2)O)C(=O)NC3C4N(C3=O)C(=C(CS4)CSC5=NN=NN5C)
C(=O)O |
| Chemical Structure |
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| ADRs Induced by Drug |
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