Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Cefazolin
Drug ID BADD_D00382
Description A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Indications and Usage Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
Marketing Status approved
ATC Code J01DB04
DrugBank ID DB01327
KEGG ID D02299
MeSH ID D002437
PubChem ID 33255
TTD Drug ID D09KDN
NDC Product Code 0409-2585; 0143-9923; 0781-3451; 0404-9833; 72572-055; 60505-6231; 0781-3450; 60505-6142; 60505-6143; 71872-7027; 44567-707; 44567-840; 52584-924; 71205-679; 72572-056; 60505-6243; 17337-0300; 0143-9924; 44567-120; 52584-087; 60505-6244; 67184-0560; 67184-1001; 0404-9835; 44567-706; 52584-923; 70518-3047; 0143-9262; 0404-9834; 71872-7141; 0781-3452; 0143-9139; 0143-9140; 0143-9261; 0143-9665; 0143-9983; 44567-708
UNII IHS69L0Y4T
Synonyms Cefazolin | Cephazolin | Cefamedin | Cefamezine | Cephamezine | Gramaxin | Kefzol | Totacef | Ancef | Cefazolin Sodium | Sodium, Cefazolin | Sodium Cephazolin | Cephazolin, Sodium | Cephazolin Sodium | Sodium, Cephazolin
Chemical Information
Molecular Formula C14H14N8O4S3
CAS Registry Number 25953-19-9
SMILES CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pharyngeal oedema10.01.05.016; 22.04.05.003; 23.04.01.0160.000049%-
Phlebitis12.02.01.002; 24.12.03.004--
Pneumonia streptococcal11.02.06.005; 22.07.06.006---
Premature baby18.04.02.0010.000097%-
Premature labour18.07.01.0020.000049%-
Presyncope02.11.04.013; 17.02.05.009; 24.06.02.0100.000049%
Proteinuria20.02.01.0110.000146%
Prothrombin level increased13.01.02.011---
Pruritus23.03.12.0010.001395%
Pruritus genital21.10.01.002; 23.03.12.008---
Pseudomembranous colitis07.19.01.003; 11.02.02.002---
Pulmonary oedema02.05.02.003; 22.01.03.003--
Pyrexia08.05.02.0030.000724%
Rash23.03.13.0010.002240%-
Rash erythematous23.03.13.0290.000238%-
Rash macular23.03.13.0030.000049%-
Rash maculo-papular23.03.13.0040.000073%
Rash papular23.03.13.0170.000131%-
Rash pruritic23.03.13.0300.000311%-
Renal failure20.01.03.005---
Renal tubular necrosis20.01.07.0030.000049%-
Respiratory distress22.02.01.0120.000049%-
Retinal artery occlusion06.10.01.005; 24.01.07.0030.000049%-
Rubber sensitivity10.01.01.025; 23.03.04.0360.000165%-
Seizure17.12.03.001--
Serum sickness-like reaction08.01.03.003; 10.01.03.005---
Shock24.06.02.0020.000073%-
Skin exfoliation23.03.07.0030.000073%-
Skin reaction10.01.03.019; 23.03.03.013---
Sneezing22.12.03.0240.000049%
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