| Drug Name |
Canakinumab |
| Drug ID |
BADD_D00345 |
| Description |
Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. Both heavy chains of canakinumab contain oligosaccharide chains linked to the protein backbone at asparagine 298 (Asn 298). Canakinumab binds to human IL-1β and neutralizes its inflammatory activity by blocking its interaction with IL-1 receptors, but it does not bind IL-1alpha or IL-1 receptor antagonist (IL-1ra). Canakinumab is marketed under the brand name Ilaris and indicated for patients 4 years of age and older to treat Familial Cold Autoinflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS), which are both part of the Cryopyrin-Associated Periodic Syndromes (CAPS) as well as for patients 2 years of age and older to treat systemic juvenile idiopathic arthritis (SJIA). Clinical trials have established the administration of canakinumab every 2 weeks to be safe and effective, offering a considerable advantage over the existing treatment with the human IL-1 receptor antagonist, anakinra, which must be injected daily and which is often poorly tolerated by patients. |
| Indications and Usage |
Used in patients 4 years of age and older to treat Familial Cold Autoinflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS), which are both part of the Cryopyrin-Associated Periodic Syndromes (CAPS) as well as for patients 2 years of age and older to treat systemic juvenile idiopathic arthritis (SJIA). |
| Marketing Status |
approved; investigational |
| ATC Code |
L04AC08 |
| DrugBank ID |
DB06168
|
| KEGG ID |
D09315
|
| MeSH ID |
C541220
|
| PubChem ID |
Not Available
|
| TTD Drug ID |
D0TD2G
|
| NDC Product Code |
0078-0734 |
| UNII |
37CQ2C7X93
|
| Synonyms |
canakinumab | Ilaris | ACZ-885 | ACZ885 | immunoglobulin G1, anti-(human interleukin 1beta) (human clone ACZ885 heavy chain V region) |
