| Pharmaceutical Information |
| Drug Name |
Calfactant |
| Drug ID |
BADD_D00342 |
| Description |
Calfactant is a sterile, non-pyrogenic lung surfactant intended for intratracheal instillation. It is an off-white suspension of an extract of natural surfactant from calf lungs suspended in 0.9% saline. Each milliliter of calfactant contains 35mg of phospholipids (including 26 mg phosphatidylcholine of which 16 mg is disaturated phosphatidylcholine) and 0.65mg of proteins including surfactant-associated proteins B and C.
Calfactant is approved for use in the United States of America. It is used to prevent or treat respiratory distress syndrome in premature infants with lung surfactant deficiency. Calfactant has been shown to decrease the incidence of respiratory distress syndrome, mortality due to respiratory distress syndrome, and air leaks associated with respiratory distress syndrome in clinical trials. It adsorbs to the air:fluid interface in the lungs and works to reduce surface tension, in a manner similar to endogenous pulmonary surfactant. |
| Indications and Usage |
Calfactant is indicated for prophylaxis therapy to prevent respiratory distress syndrome (RDS) in premature infants <29 weeks of gestational age with low lung surfactant and at high risk for RDS. Calfactant therapy is also indicated for the treatment of respiratory distress syndrome in infants 72 hours or less of age with RDS confirmed by clinical and radiologic findings and requiring endotracheal intubation. |
| Marketing Status |
approved |
| ATC Code |
Not Available |
| DrugBank ID |
DB06415
|
| KEGG ID |
D03317
|
| MeSH ID |
C117342
|
| PubChem ID |
Not Available
|
| TTD Drug ID |
D03MUT
|
| NDC Product Code |
61938-456 |
| UNII |
Q4K217VGA9
|
| Synonyms |
calfactant | bovine lung surfactant | Infasurf |
|
| Chemical Information |
| Molecular Formula |
Not Available |
| CAS Registry Number |
183325-78-2 |
| SMILES |
Not Available |
| Chemical Structure |
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| ADRs Induced by Drug |
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