Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cabergoline
Drug ID BADD_D00329
Description Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Indications and Usage For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.
Marketing Status approved
ATC Code G02CB03; N04BC06
DrugBank ID DB00248
KEGG ID D00987
MeSH ID D000077465
PubChem ID 54746
TTD Drug ID D04EGX
NDC Product Code 40016-011; 59762-1005; 47848-009; 14096-153; 23155-823; 70512-860; 50090-5834; 0093-5420; 50742-118
UNII LL60K9J05T
Synonyms Cabergoline | 1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea | FCE 21336 | FCE-21336 | Cabaser | Cabaseril | Dostinex | Galastop | Cabergoline Diphosphate | 1-Ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
Chemical Information
Molecular Formula C26H37N5O2
CAS Registry Number 81409-90-7
SMILES CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Coronary artery dissection02.02.01.004; 12.02.01.035; 24.02.02.0010.021620%-
Paradoxical drug reaction08.06.01.0140.007207%-
Peripheral swelling02.05.04.015; 08.01.03.0530.015374%-
Tumour haemorrhage16.32.03.008; 24.07.01.0280.004804%
Pituitary haemorrhage05.03.04.005; 17.08.01.019; 24.07.04.0090.028826%-
Bradyarrhythmia02.03.02.0150.004804%-
Balance disorder08.01.03.081; 17.02.02.0070.009609%-
Sudden onset of sleep17.15.04.003---
Ventricular hypokinesia02.04.02.0130.009609%-
Self-injurious ideation19.12.01.0070.004804%-
Central nervous system lesion17.02.10.0110.007207%-
Musculoskeletal stiffness15.03.05.0270.004804%-
Musculoskeletal discomfort15.03.04.001---
Foetal death08.04.01.011; 18.01.02.0030.007207%
Bipolar disorder19.16.01.0030.007207%-
Lung neoplasm malignant16.19.02.001; 22.08.01.0010.004804%-
Disturbance in sexual arousal19.08.04.003---
Drug resistance08.06.01.0050.031229%-
Hot flush08.01.03.027; 21.02.02.001; 24.03.01.005--
Brain neoplasm16.30.01.003; 17.20.01.0030.004804%-
Cardiac disorder02.11.01.003---
Impulse-control disorder19.18.01.0020.016815%-
Ischaemic stroke17.08.01.018; 24.04.06.0100.004804%-
Neoplasm progression16.16.02.0050.028826%-
Optic neuropathy06.02.08.002; 17.04.05.0050.004804%-
Cardiac valve disease02.07.02.0010.021620%-
Visual pathway disorder06.02.08.004; 17.17.01.0210.016815%-
Abnormal behaviour19.01.01.0010.004804%-
Decreased appetite08.01.09.028; 14.03.01.005--
Ill-defined disorder08.01.03.049---
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ADReCS-Target
Drug Name ADR Term Target
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