Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cabazitaxel
Drug ID BADD_D00328
Description Cabazitaxel is an anti-neoplastic used with the steroid medicine prednisone. Cabazitaxel is used to treat people with prostate cancer that has progressed despite treatment with docetaxel. Cabazitaxel is prepared by semi-synthesis with a precursor extracted from yew needles (10-deacetylbaccatin III). It was approved by the U.S. Food and Drug Administration (FDA) on June 17, 2010.
Indications and Usage For treatment of patients with hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen.
Marketing Status approved
ATC Code L01CD04
DrugBank ID DB06772
KEGG ID D09755
MeSH ID C552428
PubChem ID 9854073
TTD Drug ID D02HSB
NDC Product Code 54893-0016; 61200-101; 0024-5824; 47848-044; 63126-909; 55111-962; 68554-0080
UNII 51F690397J
Synonyms cabazitaxel | kabazitaxel | Jevtana
Chemical Information
Molecular Formula C45H57NO14
CAS Registry Number 183133-96-2
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O) O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Musculoskeletal discomfort15.03.04.001---
Transaminases increased13.03.04.036---
Angiopathy24.03.02.007---
Hot flush08.01.03.027; 21.02.02.001; 24.03.01.005--
Breast disorder21.05.04.004---
Cardiac disorder02.11.01.003---
Connective tissue disorder10.04.04.026; 15.06.01.006---
Infestation11.09.01.001; 23.11.01.002---
Limb discomfort15.03.04.014---
Malnutrition14.03.02.004---
Mediastinal disorder22.09.03.001---
Mental disorder19.07.01.002---
Decreased appetite08.01.09.028; 14.03.01.005--
Ill-defined disorder08.01.03.049---
Inner ear disorder04.04.02.002---
Blood disorder01.05.01.004---
Disease progression08.01.03.038--
Neutropenic colitis01.02.03.010; 07.08.01.014---
Cystitis noninfective20.03.02.001--
Oropharyngeal pain07.05.05.004; 22.12.03.016--
Acute kidney injury20.01.03.016--
Candida infection11.03.03.021--
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