Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cabazitaxel
Drug ID BADD_D00328
Description Cabazitaxel is an anti-neoplastic used with the steroid medicine prednisone. Cabazitaxel is used to treat people with prostate cancer that has progressed despite treatment with docetaxel. Cabazitaxel is prepared by semi-synthesis with a precursor extracted from yew needles (10-deacetylbaccatin III). It was approved by the U.S. Food and Drug Administration (FDA) on June 17, 2010.
Indications and Usage For treatment of patients with hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen.
Marketing Status approved
ATC Code L01CD04
DrugBank ID DB06772
KEGG ID D09755
MeSH ID C552428
PubChem ID 9854073
TTD Drug ID D02HSB
NDC Product Code 54893-0016; 61200-101; 0024-5824; 47848-044; 63126-909; 55111-962; 68554-0080
UNII 51F690397J
Synonyms cabazitaxel | kabazitaxel | Jevtana
Chemical Information
Molecular Formula C45H57NO14
CAS Registry Number 183133-96-2
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O) O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023; 23.03.03.081---
Hypokalaemia14.05.03.002--
Hypotension24.06.03.002--
Ileus07.13.01.001--
Immune system disorder10.02.01.001---
Infection11.01.08.002---
Influenza11.05.03.001; 22.07.02.001---
Intestinal obstruction07.13.01.002---
Laboratory test abnormal13.18.01.001---
Lacrimation increased06.08.02.004--
Lethargy08.01.01.008; 17.02.04.003; 19.04.04.004--
Leukopenia01.02.02.001---
Malaise08.01.01.003--
Menopausal symptoms21.02.02.002---
Mucosal inflammation08.01.06.002---
Muscle spasms15.05.03.004--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001---
Neuropathy peripheral17.09.03.003---
Neutropenia01.02.03.004---
Oedema08.01.07.006; 14.05.06.010---
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Orthostatic hypotension17.05.01.020; 24.06.03.004---
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Paraesthesia17.02.06.005; 23.03.03.094--
Pelvic pain07.01.06.012; 20.02.03.007; 21.10.01.001--
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