| Pharmaceutical Information |
| Drug Name |
Buspirone hydrochloride |
| Drug ID |
BADD_D00317 |
| Description |
Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class,[A180991] buspirone is a serotonin 5-HT1A receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic drugs.[L4478] Unlike many drugs used to treat anxiety, buspirone does not exhibit anticonvulsant, sedative, hypnotic, and muscle-relaxant properties. Due to these characteristics, buspirone been termed 'anxioselective'.[A180985] First synthesized in 1968 then patented in 1975,[L7375] it is commonly marketed under the brand name Buspar®. Buspirone was first approved in 1986 by the FDA [A181751] and has been used to treat anxiety disorders, such as generalized anxiety disorder (GAD), and relieve symptoms of anxiety. It has also been used as a second-line therapy for unipolar depression when the use of selective serotonin reuptake inhibitors (SSRIs) is deemed clinically inadequate or inappropriate.[L7375] The potential use of buspirone in combination with [melatonin] in depression and cognitive impairment via promoting neurogenesis has also been investigated.[A181751] |
| Indications and Usage |
Indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety.[L4478] |
| Marketing Status |
approved; investigational |
| ATC Code |
N05BE01 |
| DrugBank ID |
DB00490
|
| KEGG ID |
D00702
|
| MeSH ID |
D002065
|
| PubChem ID |
36431
|
| TTD Drug ID |
D0U2OO
|
| NDC Product Code |
49452-1310; 0093-0053; 16729-202; 16729-289; 42543-744; 55111-475; 55154-4312; 60760-548; 63187-402; 0378-1140; 65841-784; 68382-183; 68382-623; 70518-0682; 70518-1530; 70518-3065; 70518-3279; 70518-3727; 70934-967; 71335-2150; 72888-062; 12780-2940; 14593-948; 23155-097; 29300-244; 42806-085; 50090-5405; 50090-5614; 50090-5762; 53002-1424; 55154-5494; 64380-741; 68382-180; 69117-0043; 70518-2031; 70518-2987; 71335-1144; 71610-291; 71610-640; 0615-7718; 72789-139; 72888-066; 75834-267; 16729-203; 23155-025; 42543-742; 42806-086; 50090-4859; 51079-985; 51407-202; 55700-937; 59651-389; 59651-393; 63629-2409; 0378-1150; 64380-743; 68071-2995; 69117-0040; 70518-1050; 70518-3607; 71335-1605; 71335-1924; 71610-206; 0615-7714; 72189-200; 55154-5397; 59651-392; 61919-166; 63187-645; 0378-1145; 0378-1175; 64380-787; 65841-782; 69238-1116; 70518-3686; 70934-859; 71335-1752; 71335-2193; 71610-267; 71610-596; 72888-065; 42543-741; 42806-662; 50090-5797; 51079-986; 51407-203; 51407-378; 51655-015; 53002-1425; 55154-3364; 55154-4305; 63629-2408; 63629-2412; 63629-2413; 69238-1115; 69238-1117; 70518-0380; 70518-2591; 70518-2724; 70518-2803; 70518-3561; 75834-269; 29300-247; 42806-665; 50268-135; 51079-960; 51079-994; 55111-473; 61919-579; 63187-904; 65841-783; 67296-1520; 68071-2572; 68382-181; 68788-6984; 68788-7462; 69117-0042; 69238-1119; 69584-094; 70518-1747; 70518-2830; 70518-3428; 70934-850; 71205-493; 71205-799; 71335-1930; 71610-257; 71610-608; 0615-7689; 72789-140; 72888-063; 80425-0334; 0904-7121; 0904-7122; 51927-0169; 16729-200; 16729-201; 42806-083; 43063-785; 50090-4862; 50090-6188; 59651-390; 63629-2411; 64380-744; 65841-842; 68071-2987; 68382-182; 68788-8086; 69584-092; 69584-093; 70518-2660; 70518-3165; 71335-1608; 71335-2060; 71610-203; 71610-266; 71610-281; 71610-604; 72789-142; 72789-181; 72888-064; 75834-266; 0093-0054; 0093-5200; 42543-787; 42806-663; 42806-664; 55111-472; 63629-2410; 64380-742; 67296-0925; 70518-2300; 70518-2977; 71335-1105; 71335-2073; 0615-8434; 72789-141; 80425-0303; 0904-6899; 0093-1003; 23155-024; 29300-246; 42543-743; 42806-082; 42806-084; 50090-4182; 50090-5347; 51407-413; 51407-414; 51407-416; 55700-837; 55700-869; 63187-221; 63629-2415; 65841-781; 69117-0041; 70518-3091; 71205-280; 71335-0007; 71335-1938; 71335-9673; 71610-183; 71610-208; 71610-487; 75834-268; 53747-040; 23155-023; 51407-201; 51407-417; 51655-796; 53808-1102; 55111-474; 58118-0742; 63629-2414; 0378-1165; 68788-7952; 68788-7968; 69238-1118; 69584-091; 70518-3382; 71335-0222; 71335-1673; 71335-1749; 71335-2081; 71610-165; 71610-307; 71610-404; 72189-175; 75834-270; 29300-245; 43353-060; 50090-5886; 51407-415; 51655-511; 53002-1017; 59651-391 |
| UNII |
207LT9J9OC
|
| Synonyms |
Buspirone | N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide | Buspirone Hydrochloride | Hydrochloride, Buspirone | Gen-Buspirone | Gen Buspirone | Lin-Buspirone | Lin Buspirone | MJ-9022-1 | MJ 9022 1 | MJ90221 | Neurosine | Busp | Nu-Buspirone | Nu Buspirone | PMS-Buspirone | PMS Buspirone | Ratio-Buspirone | Ratio Buspirone | Anxut | Apo-Buspirone | Apo Buspirone | Buspar | Bespar | Novo-Buspirone | Novo Buspirone |
|
| Chemical Information |
| Molecular Formula |
C21H32ClN5O2 |
| CAS Registry Number |
33386-08-2 |
| SMILES |
C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4.Cl |
| Chemical Structure |
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| ADRs Induced by Drug |
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