Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Buserelin acetate
Drug ID BADD_D00315
Description Buserelin is a synthetic peptide analog of the luteinizing hormone-releasing hormone (LHRH) agonist, which stimulates the pituitary gland's gonadotrophin-releasing hormone receptor (GnRHR). It is used in prostate cancer treatment.
Indications and Usage Buserelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction.
Marketing Status approved; investigational
ATC Code L02AE01
DrugBank ID DB06719
KEGG ID D01831
MeSH ID D002064
PubChem ID 50224
TTD Drug ID D04GSY
NDC Product Code 71052-358
UNII 13U86G7YSP
Synonyms Buserelin | Buserelin Acetate | Acetate, Buserelin | Suprefact | Profact | Receptal | Tiloryth | Suprecur | Bigonist | HOE-766 | HOE 766 | HOE766
Chemical Information
Molecular Formula C62H90N16O15
CAS Registry Number 68630-75-1
SMILES CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(CC2=C C=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC( =O)N6.CC(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain lower07.01.05.010---
Abdominal pain upper07.01.05.003--
Abortion spontaneous18.01.04.001---
Accommodation disorder06.02.04.001---
Acne23.02.01.001---
Administration site reaction08.02.04.011; 12.07.04.011---
Amnesia17.03.02.001; 19.20.01.001--
Anaphylactic shock10.01.07.002; 24.06.02.004---
Anaphylactoid reaction10.01.07.003; 24.06.03.007---
Anxiety19.06.02.002--
Application site pain08.02.01.004; 12.07.01.004---
Application site reaction08.02.01.006; 12.07.01.006---
Arthralgia15.01.02.001--
Asthenia08.01.01.001---
Asthma10.01.03.010; 22.03.01.002---
Atrophy08.03.04.001---
Auditory disorder04.02.03.002---
Back pain15.03.04.005--
Blood oestrogen decreased13.10.05.010---
Blood testosterone increased13.10.05.002---
Body temperature increased13.15.01.001---
Bone pain15.02.01.001--
Breast atrophy21.05.04.005--
Breast enlargement21.05.04.001---
Breast pain21.05.05.003--
Breast tenderness21.05.05.004---
Condition aggravated08.01.03.004---
Constipation07.02.02.001--
The 1th Page    1 2 3 4 5    Next   Last    Total 6 Pages