Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Bupivacaine hydrochloride
Drug ID BADD_D00309
Description Bupivacaine is a widely used local anesthetic agent.
Indications and Usage Bupivacaine is indicated for the production of local or regional anesthesia or analgesia for surgery, for oral surgery procedures, for diagnostic and therapeutic procedures, and for obstetrical procedures. Bupivacaine is indicated to induce post-surgical analgesia in adults for up to 72 hours following arthroscopic subacromial decompression by administration into the subacromial space under direct arthroscopic visualization.[L31423] Bupivacaine, together with the NSAID [meloxicam], is indicated for the production of postsurgical analgesia in adult patients for up to 72 hours following bunionectomy, open inguinal herniorrhaphy or total knee arthroplasty.[L34100]
Marketing Status approved; investigational
ATC Code N01BB01
DrugBank ID DB00297
KEGG ID D01450
MeSH ID D002045
PubChem ID 64737
TTD Drug ID D0A0FL
NDC Product Code 73293-0002; 82449-229; 0143-9328; 0143-9329; 0143-9330; 52584-160; 52584-465; 52584-467; 55150-167; 55150-169; 55150-170; 70594-114; 71288-723; 52584-466; 55150-171; 70529-007; 70594-117; 82449-224; 82449-226; 17381-074; 38779-0524; 55150-172; 0409-1160; 70529-008; 71288-726; 0404-9826; 0404-9906; 0409-1582; 0409-1610; 70594-115; 82449-227; 12651-111; 71277-0126; 51662-1396; 52584-560; 55150-250; 63323-466; 0409-1162; 0409-1163; 0409-1587; 76420-008; 82449-223; 82449-228; 52932-0729; 0143-9332; 52584-163; 0404-9907; 0404-9945; 71872-7133; 82449-225; 62991-2014; 55150-168; 0404-9827; 0404-9947; 0409-1159; 70529-006; 71351-022; 71872-7270; 61876-0726; 55150-249; 63323-464; 63323-472; 0404-9946; 0409-1560; 71872-7217; 76420-018; 76420-230; 51927-0244; 0143-9331; 0143-9334; 0143-9335; 0409-1165; 0409-1559; 70529-005; 70594-121; 82449-230; 66206-0126; 63323-465; 63323-467; 68788-8114; 70594-118; 70594-120; 49452-1313; 51927-2358; 55579-397; 63275-9993; 66064-1031; 36000-092; 0143-9333; 50090-4516; 55154-6970
UNII 7TQO7W3VT8
Synonyms Bupivacaine | 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide | Marcain | Bupivacain Janapharm | Bupivacain-RPR | Bupivacain RPR | Bupivacaina Braun | Carbostesin | Bupivacaine Carbonate | Bupivacaine Hydrochloride | Bupivacaine Monohydrochloride, Monohydrate | Buvacaina | Dolanaest | Sensorcaine | Svedocain Sin Vasoconstr | Marcaine | Bupivacaine Anhydrous
Chemical Information
Molecular Formula C18H29ClN2O
CAS Registry Number 18010-40-7
SMILES CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Muscular weakness15.05.06.001; 17.05.03.005--
Nausea07.01.07.001--
Paraesthesia17.02.06.005; 23.03.03.094--
Paralysis17.01.04.004---
Pruritus23.03.12.001--
Respiratory paralysis17.01.04.010; 22.02.06.003---
Restlessness17.02.05.021; 19.11.02.002--
Sexual dysfunction19.08.05.002; 21.03.02.003---
Sneezing22.12.03.024--
Spinal anaesthesia25.01.03.001---
Syncope02.11.04.015; 17.02.04.008; 24.06.02.012--
Tachycardia02.03.02.007---
Tinnitus04.04.01.002; 17.04.07.004--
Tremor17.01.06.002--
Urinary incontinence17.05.01.008; 20.02.02.010--
Urinary retention20.02.02.011--
Urticaria10.01.06.001; 23.04.02.001--
Ventricular arrhythmia02.03.04.006--
Ventricular fibrillation02.03.04.008--
Ventricular tachycardia02.03.04.010--
Vision blurred06.02.06.007; 17.17.01.010--
Vomiting07.01.07.003--
CSF test abnormal13.07.02.005---
Anaesthetic complication12.02.20.002---
Myocardial depression02.04.02.015---
Anal incontinence07.01.06.029; 17.05.01.021--
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