Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol fumarate
Drug ID BADD_D00278
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage For management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI).
Marketing Status Prescription; Discontinued
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D00634
MeSH ID D017298
PubChem ID 6917733
TTD Drug ID D0K3ZR
NDC Product Code 61919-787; 52817-270; 63187-871; 68071-5097; 52817-271; 65862-087; 10920-571; 62332-603; 71335-1678; 65862-380; 65862-086; 29300-127; 65085-0051; 70954-455; 50268-127; 53747-009; 66064-1004; 52932-0720; 57451-1192; 62332-604; 38779-3142; 29300-126; 63629-6907; 70954-456; 63629-5173; 68071-1582
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C22H35NO8
CAS Registry Number 104344-23-2
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intermittent claudication24.04.03.001--Not Available
Lacrimation disorder06.08.02.010--Not Available
Laryngospasm22.04.02.002--
Libido decreased19.08.03.001; 21.03.02.005--
Malaise08.01.01.003--
Mesenteric artery thrombosis07.15.02.008; 24.01.08.003--Not Available
Muscle spasms15.05.03.004--
Muscle twitching15.05.03.005--Not Available
Myalgia15.05.02.001--
Nausea07.01.07.001--
Neck pain15.03.04.009--
Oedema08.01.07.006; 14.05.06.010--Not Available
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Orthostatic hypotension17.05.01.020; 24.06.03.004--Not Available
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Peptic ulcer07.04.07.001--Not Available
Peripheral coldness08.01.09.010; 24.04.03.006--Not Available
Peyronie's disease21.12.01.002--Not Available
Pharyngitis07.05.07.004; 11.01.13.003; 22.07.03.004--
Platelet count decreased13.01.04.001--
Polyuria20.02.03.002--Not Available
Pruritus23.03.12.001--
Psoriasis10.02.01.036; 23.03.14.002--Not Available
Purpura01.01.04.003; 23.06.01.004; 24.07.06.005--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Renal colic20.02.03.010--
Respiratory distress22.02.01.012--Not Available
Restlessness17.02.05.021; 19.11.02.002--
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