Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol
Drug ID BADD_D00277
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage For management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI).
Marketing Status Prescription; Discontinued
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D02342
MeSH ID D017298
PubChem ID 2405
TTD Drug ID D0K3ZR
NDC Product Code Not Available
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C18H31NO4
CAS Registry Number 66722-44-9
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Constipation07.02.02.001--
Coronary artery stenosis02.02.01.010; 24.04.04.0170.001342%Not Available
Cough22.02.03.001--
Cutaneous vasculitis10.02.02.003; 23.06.02.001; 24.05.02.004--Not Available
Cyanosis02.01.02.002; 22.02.02.007; 24.03.01.0070.000525%
Cystitis11.01.14.001; 20.03.02.0020.002683%
Deafness04.02.01.0010.010063%Not Available
Death08.04.01.001--
Defaecation urgency07.02.04.0010.001342%Not Available
Dehydration14.05.05.0010.008050%
Delirium19.13.02.001--
Depressed level of consciousness17.02.04.0020.006708%
Depressed mood19.15.02.001--Not Available
Depression19.15.01.001--
Depression suicidal19.15.01.0040.001342%Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis allergic10.01.03.014; 23.03.04.0030.002013%Not Available
Dermatitis bullous23.03.01.0020.001342%
Dermatitis exfoliative10.01.01.004; 23.03.07.0010.002013%
Developmental delay08.01.03.037--Not Available
Diarrhoea07.02.01.001--
Diplopia06.02.06.002; 17.17.01.0050.001342%Not Available
Discomfort08.01.08.0030.002013%Not Available
Disorientation17.02.05.015; 19.13.01.0020.003354%Not Available
Disseminated intravascular coagulation01.01.02.002; 24.01.01.0100.000525%
Disturbance in attention17.03.03.001; 19.21.02.0020.003354%
Dizziness02.01.02.004; 17.02.05.003; 24.06.02.0070.041593%
Dizziness postural02.01.02.005; 17.02.05.004; 24.06.02.0080.001342%Not Available
Drug abuse19.07.02.010--Not Available
Drug hypersensitivity10.01.01.001--Not Available
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ADReCS-Target
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