Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol
Drug ID BADD_D00277
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage For management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI).
Marketing Status Prescription; Discontinued
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D02342
MeSH ID D017298
PubChem ID 2405
TTD Drug ID D0K3ZR
NDC Product Code Not Available
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C18H31NO4
CAS Registry Number 66722-44-9
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Sinus node dysfunction02.03.03.0170.006708%
Multiple organ dysfunction syndrome08.01.03.0570.001925%
Anaplastic large cell lymphoma T- and null-cell types01.11.02.002; 16.17.02.0020.001342%Not Available
Breast cancer in situ16.10.01.007; 21.05.01.0150.002683%Not Available
Congenital umbilical hernia03.04.07.006; 07.16.03.0030.003354%Not Available
Endocarditis enterococcal02.09.03.004; 11.02.08.0040.001342%Not Available
Faeces pale07.01.03.0050.001342%Not Available
Maternal drugs affecting foetus12.03.03.006; 18.03.03.0090.002683%Not Available
Neonatal respiratory distress syndrome18.04.10.003; 22.11.02.0100.002013%Not Available
Normal newborn18.08.06.0010.001342%Not Available
Small for dates baby18.04.02.0020.013417%Not Available
Trifascicular block02.03.01.0150.002683%Not Available
Live birth18.08.02.0070.001342%Not Available
Bradycardia neonatal02.03.02.019; 18.04.07.0040.004696%Not Available
Bifascicular block02.03.01.0200.002683%Not Available
Subacute cutaneous lupus erythematosus10.04.03.012; 15.06.02.012; 23.03.02.0200.002683%Not Available
Sopor17.02.04.021; 19.02.04.0020.006708%Not Available
Gastrointestinal ischaemia07.15.02.005; 24.04.08.0070.000350%Not Available
Lung hyperinflation22.02.04.0110.002013%Not Available
Cerebellar haematoma17.08.01.045; 24.07.04.0220.001050%Not Available
Foot deformity15.10.03.0050.001342%Not Available
Stress cardiomyopathy02.04.01.012; 24.04.04.0260.002013%Not Available
Quality of life decreased13.18.01.0130.001342%Not Available
Coma scale abnormal13.07.03.0120.001342%Not Available
Varicella virus test positive13.08.03.0330.001342%Not Available
Spinal pain08.01.08.030; 15.02.01.008; 17.10.01.0200.001342%Not Available
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ADReCS-Target
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