Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bimatoprost
Drug ID BADD_D00274
Description Bimatoprost, also known as Latisse or Lumigan, belongs to a group of drugs called prostamides, which are synthetic structural analogs of prostaglandin. Bimatoprost, marketed by Allergan, is administered in both the ophthalmic solution and implant form. It has the ability to reduce ocular hypotension, proving effective in conditions such as ocular hypertension and glaucoma.[L6877,L6892,L6898,L12069] Bimatoprost is also used to treat eyelash hypotrichosis, or sparse eyelash growth.[L6910] It was initially approved by the FDA in 2001 for ocular hypertension and later approved for hypothrichosis in 2008, as eyelash growth became a desirable adverse effect for patients using this drug.[L4894]
Indications and Usage For the reduction of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication.
Marketing Status Prescription; Discontinued
ATC Code S01EE03
DrugBank ID DB00905
KEGG ID D02724
MeSH ID D000069580
PubChem ID 5311027
TTD Drug ID D0Q2XF
NDC Product Code 72266-139; 0023-3616; 82187-1001; 68083-439; 50383-912; 71052-276; 40016-005; 24002-0021; 70069-401; 0781-6206; 65129-1206; 42571-128; 62332-511; 76397-016; 73309-002; 46144-328; 54893-0009; 57741-3000; 55679-113; 82231-102; 73309-022; 0023-3205; 60505-0583; 68180-429; 50383-908; 63190-0290; 70069-402; 68245-0004; 65035-130; 72266-140; 70069-403; 62332-507; 54245-7036; 0023-9652; 68083-295; 65727-025; 72266-241; 12079-1067; 68083-296; 38779-3066; 61556-070
Synonyms Bimatoprost | Latisse | Lumigan | AGN 192024 | 192024, AGN
Chemical Information
Molecular Formula C25H37NO4
CAS Registry Number 155206-00-1
SMILES CCNC(=O)CCCC=CCC1C(CC(C1C=CC(CCC2=CC=CC=C2)O)O)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperaesthesia17.02.06.0040.001291%Not Available
Hypercholesterolaemia14.08.01.001--Not Available
Hypersensitivity10.01.03.0030.039169%
Hypertension24.08.02.001--
Hypertrichosis23.02.04.002--
Hypoaesthesia17.02.06.023--Not Available
Hypokalaemia14.05.03.002--
Infection11.01.08.002--Not Available
Influenza11.05.03.001; 22.07.02.001--Not Available
Insomnia17.15.03.002; 19.02.01.002--
Intraocular pressure increased13.07.04.0020.008609%Not Available
Iritis06.04.03.002; 10.02.01.022--Not Available
Irritability08.01.03.011; 19.04.02.013--
Keratitis06.04.02.0020.001291%
Lacrimation increased06.08.02.0040.017647%
Liver function test abnormal13.03.01.013--Not Available
Local swelling08.01.03.0130.000861%Not Available
Macular degeneration06.09.03.0010.000861%Not Available
Macular oedema06.04.06.0050.002583%Not Available
Malaise08.01.01.003--
Migraine17.14.02.001; 24.03.05.0030.001722%Not Available
Muscle spasms15.05.03.004--
Nasal congestion22.04.04.001--
Nasopharyngitis11.01.13.002; 22.07.03.002--Not Available
Nausea07.01.07.001--
Neoplasm malignant16.16.01.0010.000449%Not Available
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Ocular hyperaemia06.04.05.0040.103733%Not Available
Ocular hypertension06.03.01.0030.000861%Not Available
The 4th Page    First    Pre   4 5 6 7 8    Next   Last    Total 8 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene